| Actions d'initiés | 786 266 474 shares |
| Nombre total d'initiés | 41 |
Indice de confiance des initiés
L'indice de confiance des initiés identifie les entreprises achetées par les initiés.
Il est le résultat d'un modèle quantitatif sophistiqué et multifactoriel qui identifie les entreprises présentant les niveaux les plus élevés de capitalisation d'initiés. Le modèle de notation utilise une combinaison du nombre net d'initiés ayant acheté des actions au cours des 90 derniers jours, du nombre total d'actions achetées en pourcentage du flottant et du nombre total d'actions détenues par les initiés. Le nombre varie de 0 à 100, les chiffres les plus élevés indiquant un niveau d'accumulation supérieur à celui de ses pairs, et 50 étant la moyenne.
Fréquence de mise à jour : Quotidienne
Indice de confiance des dirigeants
L'indice de confiance des dirigeants identifie les entreprises dont les actions sont achetées par des dirigeants d'entreprise.
Par définition, les dirigeants d'entreprise sont des initiés, mais contrairement à d'autres initiés (actionnaires à 10 % et membres du conseil d'administration), les dirigeants travaillent quotidiennement pour l'entreprise et utilisent leur propre argent lorsqu'ils effectuent des opérations (les actionnaires à 10 % et les membres du conseil d'administration sont souvent des gestionnaires de fonds qui gèrent l'argent d'autrui). À ce titre, les opérations d'initiés réalisées par les dirigeants sont beaucoup plus significatives et doivent être traitées de manière appropriée.
Comme l'indice de confiance des initiés, l'indice de confiance des dirigeants est le résultat d'un modèle quantitatif sophistiqué et multifactoriel qui identifie les entreprises présentant les niveaux les plus élevés d'accumulation de dirigeants.
Fréquence de mise à jour : Quotidienne
Principaux indicateurs des initiés
Cette carte montre comment l'entreprise se positionne par rapport à divers indicateurs d'initiés. La position en centile montre comment cette entreprise se situe par rapport aux autres entreprises sur les marchés américains. Une position plus élevée indique une meilleure situation.
Par exemple, il est généralement admis que les achats d'initiés sont un indicateur positif, de sorte que les entreprises dont les achats d'initiés sont plus nombreux se positionnent mieux que celles dont les achats d'initiés sont moins nombreux (ou même les ventes d'initiés).
Pourcentage du flottant acheté par les initiés (position)
N/A
Le pourcentage du flottant acheté par les initiés est le nombre total d'actions achetées par les initiés moins le nombre total d'actions vendues par les initiés au cours des 90 derniers jours, divisé par le flottant total et multiplié par 100.
Graphique des opérations d'initiés
Les opérations d'initiés de Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock) sont présentées dans le graphique suivant. Les initiés sont des dirigeants, des administrateurs ou des investisseurs importants dans une entreprise. En général, il est illégal pour les initiés d'effectuer des opérations d'initiés dans leur entreprise sur la base d'informations matérielles non publiques. Cela ne signifie pas qu'il est illégal pour eux d'effectuer toute transaction dans leurs propres entreprises. Toutefois, ils doivent déclarer toutes les transactions à la SEC au moyen d'un formulaire 4.
Liste d'initiés et indicateurs de rentabilité
Ce tableau présente la liste des initiés connus et est généré automatiquement à partir des dépôts communiqués à la SEC. Outre les noms, le titre le plus récent et la désignation du directeur, du dirigeant ou du propriétaire à 10 %, nous indiquons les dernières participations divulguées. En outre, lorsque cela est possible, nous indiquons les performances historiques des opérations d'initiés. La performance historique des transactions est une moyenne pondérée de la performance des opérations d'achat réelles sur le marché public effectuées par l'initié. Pour plus d'informations sur le mode de calcul, regardez ce webinaire sur YouTube.
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| Initié | Profit moyen (%) | Actions détenues |
Fractionnement Ajusté |
|---|---|---|---|
| Lawrence M Alleva Director - [D] | 12 600 | 12 600 | |
| Rafael Amado President, R&D - [O] | 17 237 | 17 237 | |
|
M James Barrett
10% Owner -
|
82 978 668 | 82 978 668 | |
|
Peter J Barris
10% Owner -
|
12 000 000 | 12 000 000 | |
|
Forest Baskett
10% Owner -
|
19 500 000 | 19 500 000 | |
| Ali Behbahani Director - [D] | 0 | 0 | |
| William C JR Bertrand Chief Operating Officer - [O] | 986 352 | 986 352 | |
| Gwendolyn Knowlton Binder-Scholl Chief Technology Officer - [O] | 2 487 | 2 487 | |
| Joanna Elizabeth Brewer | 223 512 | ||
| Barbara Gayle Duncan | 144 000 | ||
|
EcoR1 Capital, LLC
10% Owner -
|
100 371 882 | 100 371 882 | |
|
Florence Anthony A. Jr.
10% Owner -
|
19 500 000 | 19 500 000 | |
| John Furey | 196 186 |
| Initié | Profit moyen (%) | Actions détenues |
Fractionnement Ajusté |
|---|---|---|---|
| Michael Garone | 0 | ||
| Samuel D Isaly Director - [D] | 6 149 377 | 6 149 377 | |
|
Patrick J Kerins
10% Owner -
|
82 978 668 | 82 978 668 | |
|
Krishna Kittu Kolluri
10% Owner -
|
118 538 000 | 118 538 000 | |
| Giles Francis Bertram Kerr | 124 000 | ||
| Jonathan Kenneth Charles Knowles Director - [D] | 7 208 768 | 7 208 768 | |
| Ian Michael Laing Director - [D] | 58 085 600 | 58 085 600 | |
| John Lunger Chief Patient Supply Officer - [O] | 7 510 | 7 510 | |
|
David M Mott
Director, 10% Owner -
[D]
|
19 500 000 | 19 500 000 | |
| Garry E Menzel Director - [D] | 75 056 | 75 056 | |
|
Nea 14 Gp, Ltd
10% Owner -
|
82 978 668 | 82 978 668 | |
|
NEA Partners 14, L.P.
10% Owner -
|
82 978 668 | 82 978 668 | |
|
New Enterprise Associates 14, L.P.
10% Owner -
|
82 978 668 | 82 978 668 | |
| James Noble Director - [D] | 0 | 0 |
| Initié | Profit moyen (%) | Actions détenues |
Fractionnement Ajusté |
|---|---|---|---|
| Elliot Norry Chief Medical Officer - [O] | 7 510 | 7 510 | |
| Orbimed Advisors Llc Director - [D] | 4 901 310 | 4 901 310 | |
| OrbiMed Capital GP V LLC Director - [D] | 4 901 310 | 4 901 310 | |
| Cintia Piccina Chief Commercial Officer - [O] | 18 421 | 18 421 | |
| Adrian Rawcliffe Chief Executive Officer, Director - [D] [O] | 44 327 | 44 327 | |
|
Scott D Sandell
10% Owner -
|
19 500 000 | 19 500 000 | |
| Charles Elliott Sigal Director - [D] | 314 100 | 314 100 | |
|
Sonsini Peter W.
10% Owner -
|
19 500 000 | 19 500 000 | |
| Helen Katrina Tayton-martin Chief Business Officer - [O] | 1 800 000 | 1 800 000 | |
| Thompson Peter A. Director - [D] | 4 901 310 | 4 901 310 | |
|
Ravi Viswanathan
10% Owner -
|
12 000 000 | 12 000 000 | |
|
Harry R Weller
10% Owner -
|
118 538 000 | 118 538 000 | |
| Gavin Wood Chief Financial Officer - [O] | 0 | 0 | |
| Tal Zvi Zaks | 144 000 |
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Historique des achats d'initiés - Analyse des bénéfices à court terme
Dans cette section, nous analysons la rentabilité de chaque achat d'initié non planifié et effectué sur le marché public dans ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). Cette analyse permet de comprendre si l'initié génère régulièrement des rendements anormaux et s'il vaut la peine d'être suivi. Cette analyse porte sur l'année qui suit chaque transaction et les résultats sont théoriques .
Le tableau suivant présente les achats sur le marché public les plus récents qui ne faisaient pas partie d'un plan de trading automatique.
Prix ajusté est le prix ajusté suite au fractionnement. Actions ajustées est le nombre d'actions ajustées suite au fractionnement.
Historique des ventes d'initiés - Analyse des pertes à court terme
Dans cette section, nous analysons l'évitement des pertes à court terme de chaque vente d'initié non planifiée et réalisée sur le marché public dans ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). Un schéma cohérent d'évitement des pertes peut suggérer que les transactions de vente futures peuvent prédire des baisses de prix. Cette analyse porte sur l'année qui suit chaque transaction, et les résultats sont théoriques .
Le tableau suivant présente les ventes les plus récentes sur le marché public qui ne faisaient pas partie d'un plan de trading automatique.
Prix ajusté est le prix ajusté suite au fractionnement. Actions ajustées est le nombre d'actions ajustées suite au fractionnement.
Historique des transactions
Click the link icon to see the full transaction history. Transactions reported as part of a 10b5-1 automatic trading plan will have an X in the column marked 10b-5.
| Date de dépôt |
Date de transaction |
Formulaire | Initié | Libellé | Nom du titre | Code | Direct | Prix d'exercice |
Prix unitaire |
Unités Modifié |
Valeur Modifiée (1K) |
Options restantes |
Actions restantes |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-09-03 | 2025-09-02 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0,0099 | -96 000 | -1 | 0 | ||||
| 2025-08-29 | 2025-08-28 | 4 | Bertrand William C JR | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0,0101 | -207 000 | -2 | 986 352 | ||||
| 2025-08-19 | 2025-08-18 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,0120 | -14 671 794 | -176 | 0 | ||||
| 2025-08-19 | 2025-08-15 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,0110 | -4 828 206 | -53 | 14 671 794 | ||||
| 2025-07-30 | 2025-07-30 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 0,1021 | -27 433 338 | -2 801 | 100 371 882 | ||||
| 2025-07-30 | 2025-07-29 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 0,1012 | -2 687 460 | -272 | 127 805 220 | ||||
| 2025-07-30 | 2025-07-28 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 0,1125 | -33 931 740 | -3 817 | 130 492 680 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5808 | -5 584 | -3 | 7 510 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5808 | -5 584 | -3 | 7 510 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5808 | -5 584 | -3 | 7 510 | ||||
| 2025-01-17 | 2025-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5808 | -30 601 | -18 | 44 327 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5748 | -12 991 | -7 | 18 421 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5748 | -29 096 | -17 | 41 582 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5879 | -17 934 | -11 | 25 711 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5879 | -12 539 | -7 | 17 801 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5748 | -9 803 | -6 | 13 756 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5879 | -8 124 | -5 | 11 516 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5879 | -4 268 | -3 | 5 845 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5748 | -9 803 | -6 | 13 756 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5879 | -5 471 | -3 | 7 623 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5879 | -4 268 | -3 | 5 845 | ||||
| 2025-01-15 | 2025-01-15 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5748 | -9 803 | -6 | 13 756 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5879 | -5 471 | -3 | 7 623 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,5879 | -4 268 | -3 | 5 845 | ||||
| 2024-06-18 | 2024-06-18 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,9300 | -24 531 | -23 | 38 293 | ||||
| 2024-03-26 | 3 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | 164 424 420 | ||||||||
| 2024-01-17 | 2024-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,6730 | -30 080 | -20 | 44 848 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,7900 | -9 304 | -7 | 14 104 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,6730 | -12 967 | -9 | 19 257 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,6730 | -5 309 | -4 | 7 785 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,7900 | -2 287 | -2 | 3 363 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,6730 | -12 805 | -9 | 19 015 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,6730 | -5 309 | -4 | 7 785 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,7900 | -4 681 | -4 | 7 023 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,6730 | -13 599 | -9 | 20 201 | ||||
| 2024-01-17 | 2024-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,6730 | -5 309 | -4 | 7 785 | ||||
| 2024-01-17 | 2024-01-16 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,7900 | -4 681 | -4 | 7 023 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,8541 | -5 220 | -4 | 7 874 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,8367 | -4 009 | -3 | 6 104 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,8541 | -17 257 | -15 | 26 388 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,8367 | -11 945 | -10 | 18 395 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,8541 | -5 220 | -4 | 7 874 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,8367 | -4 009 | -3 | 6 104 | ||||
| 2024-01-12 | 2024-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,8541 | -7 799 | -7 | 11 841 | ||||
| 2024-01-12 | 2024-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,8367 | -4 009 | -3 | 6 104 | ||||
| 2023-09-01 | 2023-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,7800 | -2 403 | -2 | 3 449 | ||||
| 2023-08-01 | 2023-08-01 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,9056 | -3 096 | -3 | 4 718 | ||||
| 2023-07-10 | 2023-07-10 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,9108 | -47 702 | -43 | 75 056 | ||||
| 2023-06-27 | 2023-06-27 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 0,9200 | -2 333 | -2 | 3 519 | ||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | D | 209 931 | 209 931 | ||||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | I | 200 647 | 200 647 | ||||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | I | 200 646 | 200 646 | ||||||
| 2023-01-31 | 2023-01-31 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,8696 | -11 890 | -22 | 19 535 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,8580 | -4 440 | -8 | 7 264 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,8580 | -10 057 | -19 | 13 351 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,8580 | -4 440 | -8 | 7 264 | ||||
| 2023-01-17 | 2023-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,8580 | -2 159 | -4 | 3 491 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7060 | -4 973 | -8 | 8 121 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7468 | -3 843 | -7 | 6 270 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7060 | -4 973 | -8 | 8 121 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7468 | -3 843 | -7 | 6 270 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7060 | -7 449 | -13 | 12 191 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7468 | -3 843 | -7 | 6 270 | ||||
| 2023-01-12 | 2023-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7060 | -18 763 | -32 | 24 882 | ||||
| 2023-01-12 | 2023-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7468 | -13 042 | -23 | 17 298 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,6940 | -3 584 | -6 | 5 781 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,6940 | -5 073 | -9 | 6 631 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,6940 | -876 | -1 | 1 361 | ||||
| 2023-01-04 | 2023-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,6940 | -1 100 | -2 | 1 725 | ||||
| 2022-09-01 | 2022-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,9689 | -2 536 | -5 | 3 316 | ||||
| 2022-08-01 | 2022-08-01 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7735 | -2 983 | -5 | 4 829 | ||||
| 2022-08-01 | 2022-08-01 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,7735 | -21 040 | -37 | 34 824 | ||||
| 2022-07-05 | 2022-07-05 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,6781 | -1 973 | -3 | 3 104 | ||||
| 2022-06-27 | 2022-06-27 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,6300 | -2 562 | -4 | 3 290 | ||||
| 2022-05-23 | 2022-05-20 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0,2904 | 39 000 | 11 | 96 000 | ||||
| 2022-05-04 | 2022-05-04 | 4 | Brewer Joanna Elizabeth | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 223 512 | 223 512 | |||||
| 2022-05-04 | 2022-05-04 | 4 | Brewer Joanna Elizabeth | ADAP | Option to purchase Ordinary Shares | D | 0,30 | 333 792 | 333 792 | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 335 184 | 335 184 | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 754 200 | 754 200 | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | 0,45 | 3 376 992 | 3 376 992 | |||||
| 2022-01-18 | 2022-01-18 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,1918 | -4 368 | -14 | 7 336 | ||||
| 2022-01-18 | 2022-01-18 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,1918 | -4 368 | -14 | 7 336 | ||||
| 2022-01-18 | 2022-01-18 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,1918 | -2 121 | -7 | 3 529 | ||||
| 2022-01-18 | 2022-01-18 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,1918 | -11 096 | -35 | 12 312 | ||||
| 2022-01-13 | 2022-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 314 256 | 314 256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0,60 | 1 407 072 | 1 407 072 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 314 256 | 314 256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0,60 | 1 407 072 | 1 407 072 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,5441 | -2 248 | -8 | 3 754 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,5567 | -3 770 | -13 | 6 343 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 314 256 | 314 256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0,60 | 1 407 072 | 1 407 072 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,5441 | -1 076 | -4 | 1 749 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,5567 | -3 770 | -13 | 6 343 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,5441 | -854 | -3 | 1 383 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,5567 | -3 770 | -13 | 6 343 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,5441 | -3 046 | -11 | 3 356 | ||||
| 2022-01-13 | 2022-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,5567 | -14 362 | -51 | 15 978 | ||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 471 360 | 471 360 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0,60 | 2 110 608 | 2 110 608 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 1 047 480 | 1 047 480 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,60 | 4 690 224 | 4 690 224 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 314 256 | 314 256 | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0,60 | 1 407 072 | 1 407 072 | |||||
| 2022-01-05 | 2022-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 4,0642 | -3 490 | -14 | 5 873 | ||||
| 2022-01-05 | 2022-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 4,0642 | -1 070 | -4 | 1 755 | ||||
| 2022-01-05 | 2022-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 4,0642 | -849 | -3 | 1 388 | ||||
| 2022-01-05 | 2022-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 4,0642 | -5 532 | -22 | 6 172 | ||||
| 2021-09-01 | 2021-09-01 | 4 | Rawcliffe Adrian | ADAP] | American Depositary Shares representing Ordinary Shares | D | 5,1950 | -2 782 | -14 | 3 070 | ||||
| 2021-08-02 | 2021-08-02 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 3,5848 | -2 939 | -11 | 4 873 | ||||
| 2021-07-02 | 2021-07-01 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 0,71 | 379 788 | 379 788 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 0,71 | 505 918 | 505 918 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 0,71 | 474 385 | 474 385 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 0,71 | 474 385 | 474 385 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0,71 | 379 788 | 379 788 | |||||
| 2021-07-02 | 2021-07-02 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 4,2649 | -4 375 | -19 | 7 329 | ||||
| 2021-07-02 | 2021-07-01 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 0,71 | 579 494 | 579 494 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0,71 | 379 788 | 379 788 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | 0,71 | 379 788 | 379 788 | |||||
| 2021-07-02 | 2021-07-02 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 4,2649 | -1 907 | -8 | 3 170 | ||||
| 2021-06-28 | 2021-06-28 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 4,3700 | -2 794 | -12 | 3 058 | ||||
| 2021-06-03 | 2021-06-01 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 0,7900 | 12 600 | 10 | 12 600 | ||||
| 2021-03-03 | 2021-03-03 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0,1570 | 1 785 000 | 280 | 1 800 000 | ||||
| 2021-01-19 | 2021-01-19 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,6695 | -2 111 | -12 | 3 539 | ||||
| 2021-01-19 | 2021-01-19 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,6695 | -4 358 | -25 | 7 346 | ||||
| 2021-01-19 | 2021-01-19 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,6695 | -9 879 | -56 | 13 529 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 6,1522 | -2 234 | -14 | 3 768 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 6,1522 | -1 058 | -7 | 1 767 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 6,1522 | -841 | -5 | 1 396 | ||||
| 2021-01-12 | 2021-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 6,1522 | -2 707 | -17 | 3 695 | ||||
| 2021-01-11 | 2021-01-11 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 242 712 | 242 712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 1,03 | 1 086 816 | 1 086 816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 242 712 | 242 712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 1,03 | 1 086 816 | 1 086 816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 728 160 | 728 160 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 1,03 | 3 260 400 | 3 260 400 | |||||
| 2021-01-11 | 2021-01-11 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 242 712 | 242 712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 1,03 | 1 086 816 | 1 086 816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 242 712 | 242 712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 1,03 | 1 086 816 | 1 086 816 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 242 712 | 242 712 | |||||
| 2021-01-11 | 2021-01-11 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 1,03 | 1 086 816 | 1 086 816 | |||||
| 2021-01-05 | 2021-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,3279 | -1 065 | -6 | 1 760 | ||||
| 2021-01-05 | 2021-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,3279 | -845 | -5 | 1 392 | ||||
| 2021-01-05 | 2021-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,3279 | -3 499 | -19 | 5 864 | ||||
| 2021-01-05 | 2021-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,3279 | -4 967 | -26 | 6 737 | ||||
| 2020-12-16 | 2020-12-14 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0,6896 | 24 000 | 17 | 57 000 | ||||
| 2020-12-15 | 2020-12-14 | 4 | Bertrand William C JR | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0,6948 | 207 000 | 144 | 284 808 | ||||
| 2020-09-02 | 2020-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 8,5149 | -2 776 | -24 | 3 076 | ||||
| 2020-08-04 | 2020-08-03 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 9,2500 | -2 788 | -26 | 3 064 | ||||
| 2020-08-04 | 2020-08-03 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | 8,7409 | -200 000 | -1 748 | 0 | ||||
| 2020-08-04 | 2020-08-03 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 9,2500 | -4 823 | -45 | 8 066 | ||||
| 2020-07-01 | 2020-07-01 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 1,67 | 184 258 | 184 258 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | 1,67 | 196 186 | 196 186 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 1,67 | 197 678 | 197 678 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 1,67 | 144 000 | 144 000 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 1,67 | 144 000 | 144 000 | |||||
| 2020-07-01 | 2020-07-01 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 1,67 | 226 753 | 226 753 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 1,67 | 184 258 | 184 258 | |||||
| 2020-07-01 | 2020-07-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 1,67 | 179 785 | 179 785 | |||||
| 2020-06-30 | 2020-06-29 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 1,6200 | 33 000 | 53 | 33 000 | ||||
| 2020-06-11 | 2020-06-09 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1,8900 | 12 900 | 24 | 12 900 | ||||
| 2020-06-02 | 2020-05-29 | 4 | Noble James | ADAP | American Depositary Shares | D | 9,3320 | -500 000 | -4 666 | 0 | ||||
| 2020-04-01 | 2020-04-01 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 565 000 | 565 000 | |||||
| 2020-04-01 | 2020-04-01 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | 0,45 | 2 500 000 | 2 500 000 | |||||
| 2020-04-01 | 2020-04-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0,45 | 31 000 | 31 000 | |||||
| 2020-01-28 | 2020-01-24 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,6667 | 7 500 000 | 5 000 | 19 500 000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,6667 | 7 500 000 | 5 000 | 19 500 000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,6667 | 7 500 000 | 5 000 | 19 500 000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,6667 | 7 500 000 | 5 000 | 19 500 000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,6667 | 7 500 000 | 5 000 | 19 500 000 | ||||
| 2020-01-28 | 2020-01-24 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,6667 | 7 500 000 | 5 000 | 19 500 000 | ||||
| 2020-01-17 | 2020-01-16 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 135 600 | 135 600 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | 0,74 | 201 600 | 201 600 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 280 896 | 280 896 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0,74 | 1 257 744 | 1 257 744 | |||||
| 2020-01-17 | 2020-01-16 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 280 896 | 280 896 | |||||
| 2020-01-17 | 2020-01-16 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0,74 | 1 257 744 | 1 257 744 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 561 792 | 561 792 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,74 | 2 515 536 | 2 515 536 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 280 896 | 280 896 | |||||
| 2020-01-17 | 2020-01-16 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0,74 | 1 257 744 | 1 257 744 | |||||
| 2020-01-15 | 2020-01-13 | 4 | Noble James | ADAP | American Depositary Shares | D | 5,0000 | -200 000 | -1 000 | 0 | ||||
| 2020-01-15 | 2020-01-13 | 4 | Noble James | ADAP | American Depositary Shares | D | 4,0000 | -100 000 | -400 | 0 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,1347 | -3 236 | -17 | 3 166 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,1347 | -1 144 | -6 | 1 681 | ||||
| 2020-01-15 | 2020-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | 5,0000 | -50 000 | -250 | 0 | ||||
| 2020-01-15 | 2020-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | 4,0000 | -50 000 | -200 | 0 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,1347 | -2 397 | -12 | 3 605 | ||||
| 2020-01-15 | 2020-01-14 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,1347 | -911 | -5 | 1 326 | ||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 5 358 | ||||||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 5 358 | ||||||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 5 358 | ||||||||
| 2020-01-07 | 2020-01-06 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,2000 | -5 900 | -7 | 5 804 | ||||
| 2020-01-07 | 2020-01-06 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,2000 | -3 731 | -4 | 5 632 | ||||
| 2020-01-07 | 2020-01-06 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | 1,2000 | -1 148 | -1 | 1 677 | ||||
| 2019-09-03 | 2019-09-01 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 140 448 | 140 448 | |||||
| 2019-09-03 | 2019-09-01 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,27 | 628 872 | 628 872 | |||||
| 2019-08-07 | 2019-08-06 | 4 | Amado Rafael | ADAP | American Depositary Shares representing Ordinary Shares | D | 2,0600 | -11 043 | -23 | 17 237 | ||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 57 612 | ||||||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 57 612 | ||||||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 57 612 | ||||||||
| 2019-08-05 | 2019-08-01 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 187 500 | 187 500 | |||||
| 2019-08-05 | 2019-08-01 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | 0,55 | 839 568 | 839 568 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 0,61 | 234 407 | 234 407 | |||||
| 2019-07-03 | 2019-07-02 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 0,61 | 350 947 | 350 947 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 0,61 | 271 209 | 271 209 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 0,61 | 124 000 | 124 000 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 0,61 | 234 407 | 234 407 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 0,61 | 124 000 | 124 000 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | 0,61 | 240 541 | 240 541 | |||||
| 2019-07-03 | 2019-07-02 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0,61 | 124 000 | 124 000 | |||||
| 2019-06-27 | 2019-06-27 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 140 448 | 140 448 | |||||
| 2019-06-27 | 2019-06-27 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,68 | 628 872 | 628 872 | |||||
| 2019-05-17 | 2019-05-16 | 4 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 0,1430 | 1 773 100 | 254 | 1 773 100 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,3694 | -3 084 | -17 | 3 318 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Amado Rafael | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,3694 | -3 028 | -16 | 4 974 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,3694 | -2 271 | -12 | 3 731 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares representing Ordinary Shares | D | 5,3694 | -1 514 | -8 | 2 487 | ||||
| 2019-01-08 | 2019-01-04 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 561 792 | 561 792 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0,89 | 2 515 536 | 2 515 536 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 224 724 | 224 724 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0,89 | 1 006 224 | 1 006 224 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 280 896 | 280 896 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,89 | 1 257 744 | 1 257 744 | |||||
| 2019-01-08 | 2019-01-04 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 224 724 | 224 724 | |||||
| 2019-01-08 | 2019-01-04 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0,89 | 1 006 224 | 1 006 224 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 224 724 | 224 724 | |||||
| 2019-01-08 | 2019-01-04 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0,89 | 1 006 224 | 1 006 224 | |||||
| 2018-12-19 | 2018-12-17 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 0,8400 | 47 280 | 40 | 47 280 | ||||
| 2018-10-02 | 2018-10-01 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares | D | 13,7900 | -25 000 | -345 | 0 | ||||
| 2018-09-10 | 2018-09-07 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRIS PETER J See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 12 000 000 | 20 000 | 12 000 000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BASKETT FOREST See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 12 000 000 | 20 000 | 12 000 000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 12 000 000 | 20 000 | 12 000 000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Florence Anthony A. Jr. See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 12 000 000 | 20 000 | 12 000 000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | MOTT DAVID M See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 12 000 000 | 20 000 | 12 000 000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | SANDELL SCOTT D See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 12 000 000 | 20 000 | 12 000 000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Sonsini Peter W. See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 12 000 000 | 20 000 | 12 000 000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Viswanathan Ravi See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 12 000 000 | 20 000 | 12 000 000 | ||||
| 2018-09-10 | 2018-09-07 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,6667 | 3 000 000 | 5 000 | 82 978 668 | ||||
| 2018-08-31 | 2018-08-29 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares | D | 10,2500 | -25 000 | -256 | 0 | ||||
| 2018-08-07 | 2018-08-06 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 678 720 | 678 720 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 2,18 | 154 809 | 154 809 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 2,18 | 158 233 | 158 233 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 2,18 | 124 000 | 124 000 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 2,18 | 124 000 | 124 000 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 2,18 | 124 000 | 124 000 | |||||
| 2018-06-26 | 2018-06-22 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 2,18 | 154 809 | 154 809 | |||||
| 2018-06-26 | 2018-06-22 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 2,18 | 187 330 | 187 330 | |||||
| 2018-06-06 | 2018-06-06 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,4900 | -1 600 | -22 | 4 901 310 | ||||
| 2018-06-06 | 2018-06-04 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,5700 | -17 100 | -232 | 4 902 910 | ||||
| 2018-06-06 | 2018-06-06 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,4900 | -1 600 | -22 | 4 901 310 | ||||
| 2018-06-06 | 2018-06-04 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,5700 | -17 100 | -232 | 4 902 910 | ||||
| 2018-06-01 | 2018-06-01 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,4900 | -50 000 | -674 | 4 920 010 | ||||
| 2018-06-01 | 2018-05-30 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,5200 | -121 000 | -1 636 | 4 970 010 | ||||
| 2018-06-01 | 2018-06-01 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,4900 | -50 000 | -674 | 4 920 010 | ||||
| 2018-06-01 | 2018-05-30 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,5200 | -121 000 | -1 636 | 4 970 010 | ||||
| 2018-05-16 | 2018-05-14 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,5000 | -10 300 | -139 | 5 091 010 | ||||
| 2018-05-16 | 2018-05-14 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 13,5000 | -10 300 | -139 | 5 091 010 | ||||
| 2018-03-29 | 2018-03-29 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11,5300 | -31 983 | -369 | 5 101 310 | ||||
| 2018-03-29 | 2018-03-27 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11,5000 | -1 016 084 | -11 685 | 5 133 293 | ||||
| 2018-03-29 | 2018-03-29 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11,5300 | -31 983 | -369 | 5 101 310 | ||||
| 2018-03-29 | 2018-03-27 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 11,5000 | -1 016 084 | -11 685 | 5 133 293 | ||||
| 2018-03-28 | 2018-03-27 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-28 | 2018-03-27 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9167 | 6 000 000 | 11 500 | 79 978 672 | ||||
| 2018-03-28 | 2018-03-26 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9041 | 571 164 | 1 088 | 73 978 672 | ||||
| 2018-03-23 | 2018-03-23 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-23 | 2018-03-23 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9462 | 294 090 | 572 | 73 407 508 | ||||
| 2018-03-23 | 2018-03-22 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,9040 | 869 574 | 1 656 | 73 113 418 | ||||
| 2018-03-23 | 2018-03-21 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 1,8105 | 104 844 | 190 | 72 243 844 | ||||
| 2018-03-22 | 2018-03-20 | 4 | Rawcliffe Adrian | ADAP | Ordinary Shares | D | 1,7100 | -600 000 | -1 026 | 0 | ||||
| 2018-01-17 | 2018-01-12 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 384 120 | 384 120 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 1,30 | 1 719 936 | 1 719 936 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 192 060 | 192 060 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 1,30 | 859 968 | 859 968 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 144 048 | 144 048 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | 1,30 | 644 976 | 644 976 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 96 036 | 96 036 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 1,30 | 429 984 | 429 984 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 153 648 | 153 648 | |||||
| 2018-01-17 | 2018-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 1,30 | 687 984 | 687 984 | |||||
| 2018-01-17 | 2018-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0,00 | 153 648 | 153 648 | |||||
| 2018-01-17 | 2018-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 1,30 | 687 984 | 687 984 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0,75 | 144 000 | 144 000 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | 0,75 | 228 765 | 228 765 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 0,75 | 220 788 | 220 788 | |||||
| 2017-07-03 | 2017-07-03 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 0,75 | 302 561 | 302 561 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 0,75 | 243 724 | 243 724 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 0,75 | 144 000 | 144 000 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 0,75 | 220 788 | 220 788 | |||||
| 2017-07-03 | 2017-07-03 | 4 | Thompson Peter A. | ADAP | Option to purchase Ordinary Shares | D | 0,75 | 223 779 | 223 779 | |||||
| 2017-03-28 | 2017-03-27 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 4,2000 | 1 190 476 | 5 000 | 6 149 377 | ||||
| 2017-03-28 | 2017-03-27 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | 4,2000 | 1 190 476 | 5 000 | 6 149 377 | ||||
| 2017-03-28 | 2017-03-27 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-03-28 | 2017-03-27 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 0,7000 | 12 870 000 | 9 009 | 72 139 000 | ||||
| 2017-01-18 | 2017-01-13 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 0,72 | 2 072 976 | 2 072 976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 0,72 | 2 072 976 | 2 072 976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 0,72 | 2 072 976 | 2 072 976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 0,72 | 2 072 976 | 2 072 976 | |||||
| 2017-01-18 | 2017-01-13 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 0,72 | 2 072 976 | 2 072 976 | |||||
| 2016-12-01 | 2016-11-29 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | 0,81 | 288 000 | 288 000 | |||||
| 2016-12-01 | 2016-11-29 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | 0,81 | 288 000 | 288 000 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Thompson Peter A. | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 186 142 | 186 142 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 196 678 | 196 678 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 184 562 | 184 562 | |||||
| 2016-08-12 | 2016-08-11 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 191 410 | 191 410 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Laing Ian Michael | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 144 000 | 144 000 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 184 562 | 184 562 | |||||
| 2016-08-12 | 2016-08-11 | 4 | Knowles Jonathan Kenneth Charles | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 217 222 | 217 222 | |||||
| 2016-05-25 | 2016-05-24 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10,4800 | 518 400 | 5 433 | 29 753 404 | ||||
| 2016-05-25 | 2016-05-23 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10,4000 | 1 191 600 | 12 393 | 29 235 004 | ||||
| 2016-05-25 | 2016-05-20 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10,0400 | 2 400 | 24 | 28 043 404 | ||||
| 2016-05-25 | 2016-05-24 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10,4800 | 518 400 | 5 433 | 29 753 404 | ||||
| 2016-05-25 | 2016-05-23 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10,4000 | 1 191 600 | 12 393 | 29 235 004 | ||||
| 2016-05-25 | 2016-05-20 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 10,0400 | 2 400 | 24 | 28 043 404 | ||||
| 2016-05-19 | 2016-05-19 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1,5600 | 15 000 | 23 | 314 100 | ||||
| 2016-05-18 | 2016-05-18 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1,5500 | 15 000 | 23 | 299 100 | ||||
| 2016-05-18 | 2016-05-17 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1,5300 | 15 000 | 23 | 284 100 | ||||
| 2016-05-18 | 2016-05-16 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 1,5000 | 15 000 | 22 | 269 100 | ||||
| 2016-01-20 | 2016-01-18 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 939 948 | 939 948 | |||||
| 2016-01-20 | 2016-01-18 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 704 961 | 704 961 | |||||
| 2016-01-20 | 2016-01-18 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 939 948 | 939 948 | |||||
| 2016-01-20 | 2016-01-18 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 1 968 016 | 1 968 016 | |||||
| 2016-01-20 | 2016-01-18 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | 1,27 | 939 948 | 939 948 | |||||
| 2016-01-04 | 3 | Weller Harry R See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | Weller Harry R See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | Sonsini Peter W. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | Sonsini Peter W. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | KOLLURI KRISHNA KITTU See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | KOLLURI KRISHNA KITTU See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | Florence Anthony A. Jr. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | Florence Anthony A. Jr. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | BARRIS PETER J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | BARRIS PETER J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118 538 000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118 538 000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118 538 000 | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | 118 538 000 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 561 138 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 561 138 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 359 976 | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 359 976 | ||||||||
| 2016-01-04 | 3 | Laing Ian Michael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 58 085 600 | ||||||||
| 2016-01-04 | 3 | Laing Ian Michael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 58 085 600 | ||||||||
| 2016-01-04 | 3 | Alleva Lawrence M | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 141 168 | ||||||||
| 2016-01-04 | 3 | Alleva Lawrence M | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 141 168 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 7 208 768 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 14 205 784 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 7 208 768 | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 14 205 784 | ||||||||
| 2016-01-04 | 3 | Amado Rafael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 192 000 | ||||||||
| 2016-01-04 | 3 | Amado Rafael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 192 000 | ||||||||
| 2016-01-04 | 3 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 3 630 000 | ||||||||
| 2016-01-04 | 3 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 3 630 000 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 21 145 200 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 12 372 600 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 21 145 200 | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | 12 372 600 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30 673 708 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53 449 304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30 673 708 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53 449 304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53 449 304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30 673 708 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53 449 304 | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30 673 708 | ||||||||
| 2016-01-04 | 3 | BASKETT FOREST See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | BASKETT FOREST See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | BARRETT M JAMES See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | BARRETT M JAMES See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | MOTT DAVID M See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | MOTT DAVID M See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | KERINS PATRICK J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | KERINS PATRICK J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | SANDELL SCOTT D See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | SANDELL SCOTT D See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53 449 304 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30 673 708 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 53 449 304 | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | 30 673 708 | ||||||||
| 2016-01-04 | 3 | Viswanathan Ravi See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 | ||||||||
| 2016-01-04 | 3 | Viswanathan Ravi See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | 118 538 000 |
P
Achat sur le marché public ou privé d'un titre non dérivé ou dérivé
S
Vente sur le marché public ou privé d'un titre non dérivé ou dérivé
A
Attribution, récompense ou autre acquisition de titres de l'entreprise (comme une option).
C
Conversion d'un produit dérivé
D
Vente ou transfert de titres à l'entreprise
F
Paiement du prix d'exercice ou de la dette fiscale en utilisant une partie des titres reçus de l'entreprise
G
Don de titres par ou à l'initié
K
Swaps d'actions et opérations de couverture similaires
M
Exercice ou conversion d'un titre dérivé reçu de l'entreprise (tel qu'une option)
V
Une transaction déclarée volontairement sur le formulaire 4
J
Autre (accompagnée d'une note de bas de page décrivant la transaction)
