LSAQ / LifeSci Acquisition II Corp - Documents déposés auprès de la SEC, rapport annuel, procuration

LifeSci Acquisition II Corp
US ˙ NASDAQ ˙ US53229E1038
CE SYMBOLE N'EST PLUS ACTIF

Statistiques de base
CIK 1819113
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to LifeSci Acquisition II Corp
SEC Filings (Chronological Order)
Cette page fournit une liste complète et chronologique des documents déposés auprès de la SEC, à l'exclusion des documents relatifs à la participation que nous fournissons ailleurs.
March 25, 2024 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-39727 Science 37 Holdings, Inc. (Exact name of registrant as specified i

March 14, 2024 SC 13D/A

LSAQ / LifeSci Acquisition II Corp / Thermo Fisher Scientific Inc. - AMENDMENT NO. 1 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCIENCE 37 HOLDINGS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644108 (CUSIP Number) Michael A. Boxer Senior Vice President and General Counsel Thermo Fisher Scientific Inc. 168 Third Avenue Walth

March 13, 2024 SC 13D/A

LSAQ / LifeSci Acquisition II Corp / Redmile Group, LLC - SC 13D/A Activist Investment

UNITED STATES SECURITIES & EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* Science 37 Holdings, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 808644207 (CUSIP Number) Redmile Group, LLC Attn: Jennifer Ciresi One Letterman Drive, Bldg D, Ste D3-300 San Francisco, CA 94129 Attention:

March 12, 2024 POS AM

As filed with the Securities and Exchange Commission on March 12, 2024

As filed with the Securities and Exchange Commission on March 12, 2024 Registration No.

March 12, 2024 EX-99.1 (A)(5)(B)

# # #

Exhibit 99.(a)(5)(B) eMed completes tender offer for all outstanding shares of Science 37 March 12, 2024 — eMed, LLC (“eMed”) today announced the successful completion of the previously announced tender offer by its wholly-owned subsidiary, Marlin Merger Sub Corporation (“Purchaser”), for all the outstanding shares of common stock, par value $0.0001 per share, of Science 37 Holdings, Inc. (NASDAQ:

March 12, 2024 SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) Science 37 Holdings, Inc. (Name of Subject Co

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) Science 37 Holdings, Inc. (Name of Subject Company) Science 37 Holdings, Inc. (Name of Persons Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644207

March 12, 2024 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 2) SCIENCE 37 HOLDINGS, INC. (Name of Subject Company

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 2) SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer)) MARLIN MERGER SUB CORPORATION a wholly-owned subsidiary of eMED, LLC (Name of Filing Persons (Offerors)) Common Stock, $0.0001 Par Value (Ti

March 12, 2024 S-8 POS

As filed with the Securities and Exchange Commission on March 12, 2024

As filed with the Securities and Exchange Commission on March 12, 2024 Registration No.

March 12, 2024 EX-3.2

SECOND AMENDED AND RESTATED BYLAWS SCIENCE 37 HOLDINGS, INC. (a Delaware corporation) ARTICLE I

Exhibit 3.2 SECOND AMENDED AND RESTATED BYLAWS OF SCIENCE 37 HOLDINGS, INC. (a Delaware corporation) ARTICLE I OFFICES SECTION 1. Registered Office. The registered office of Science 37 Holdings, Inc. (the “Corporation”) shall be established and maintained at the office of The Corporation Trust Company, in the City of Wilmington, in the County of New Castle, in the State of Delaware, and said compa

March 12, 2024 S-8 POS

As filed with the Securities and Exchange Commission on March 12, 2024

As filed with the Securities and Exchange Commission on March 12, 2024 Registration No.

March 12, 2024 POS AM

As filed with the Securities and Exchange Commission on March 12, 2024

As filed with the Securities and Exchange Commission on March 12, 2024 Registration No.

March 12, 2024 8-K

Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 11, 2024 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 001-39727 84-4278203 (Commissio

March 12, 2024 S-8 POS

As filed with the Securities and Exchange Commission on March 12, 2024

As filed with the Securities and Exchange Commission on March 12, 2024 Registration No.

March 12, 2024 S-8 POS

As filed with the Securities and Exchange Commission on March 12, 2024

As filed with the Securities and Exchange Commission on March 12, 2024 Registration No.

March 12, 2024 EX-99.(A)(5)(H)

# # #

Exhibit (a)(5)(H) eMed completes tender offer for all outstanding shares of Science 37 March 12, 2024 — eMed, LLC (“eMed”) today announced the successful completion of the previously announced tender offer by its wholly-owned subsidiary, Marlin Merger Sub Corporation (“Purchaser”), for all the outstanding shares of common stock, par value $0.

March 12, 2024 EX-3.1

Third Amended and Restated Certificate of Incorporation Science 37 Holdings, Inc.

Exhibit 3.1 Third Amended and Restated Certificate of Incorporation of Science 37 Holdings, Inc. 1. The name of the corporation is “Science 37 Holdings, Inc.” (the “Corporation”). 2. The address of the Corporation’s registered office is The Corporation Trust Company, 1209 Orange Street, Wilmington 19801, in the County of New Castle. The Corporation Trust Company is the Corporation’s registered age

March 4, 2024 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 1) SCIENCE 37 HOLDINGS, INC. (Name of Subject Company

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 1) SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer)) MARLIN MERGER SUB CORPORATION a wholly-owned subsidiary of eMED, LLC (Name of Filing Persons (Offerors)) Common Stock, $0.0001 Par Value (Ti

March 4, 2024 SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) Science 37 Holdings, Inc. (Name of Subject Co

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) Science 37 Holdings, Inc. (Name of Subject Company) Science 37 Holdings, Inc. (Name of Persons Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644207

February 12, 2024 EX-99.(A)(1)(A)

Offer to Purchase for Cash All Outstanding Shares of Common Stock of Science 37 Holdings, Inc. $5.75 Net Per Share Marlin Merger Sub Corporation a wholly-owned subsidiary of eMed, LLC THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT 12:00 MIDNIGHT, NEW

TABLE OF CONTENTS  Exhibit (a)(1)(A) Offer to Purchase for Cash All Outstanding Shares of Common Stock of Science 37 Holdings, Inc.

February 12, 2024 EX-99.(D)(3)

eMed, LLC 990 Biscayne Blvd. Suite 1501 Miami, FL 33132

Exhibit (d)(3) eMed, LLC 990 Biscayne Blvd. Suite 1501 Miami, FL 33132 December 20, 2023 Confidential Science 37 Holdings, Inc. 800 Park Offices Drive Suite 3606 Research Triangle Park, NC 27709 Re: Proposed Transaction Ladies and Gentlemen: This letter agreement (this “Letter Agreement”) is entered into by (i) eMed, LLC (“eMed”), and (ii) Science 37 Holdings, Inc. (“Science 37”). Each of eMed and

February 12, 2024 EX-99.(A)(1)(B)

Letter of Transmittal to Tender Shares of Common Stock of SCIENCE 37 HOLDINGS, INC. at $5.75 Net Per Share in Cash Pursuant to the Offer to Purchase dated February 12, 2024 by Marlin Merger Sub Corporation, a wholly-owned subsidiary of eMed, LLC

 Exhibit (a)(1)(B) Letter of Transmittal to Tender Shares of Common Stock of SCIENCE 37 HOLDINGS, INC.

February 12, 2024 EX-99.(D)(2)

[SNCE LETTERHEAD]

Exhibit (d)(2) [SNCE LETTERHEAD] November 13, 2023 eMed LLC 990 Biscayne Blvd., Suite 1501 Miami, Florida 33132 Attention: Michael Cole, President and Chief Financial Officer Re: Confidentiality Agreement Ladies and Gentlemen: In connection with the consideration by eMed LLC, a Delaware limited liability company (“you” or “your”) of a possible negotiated acquisition of (a “Possible Transaction”) S

February 12, 2024 EX-FILING FEES

Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer)) MARLIN MERGER SUB CORPORATION a wholly owned subsidiary of eMED, LLC (Names of Filing Persons (Offerors))

Exhibit 107 Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) SCIENCE 37 HOLDINGS, INC.

February 12, 2024 EX-99.(E)(2)

[SNCE LETTERHEAD]

  Exhibit (e)(2)   [SNCE LETTERHEAD]   November 13, 2023   eMed LLC  990 Biscayne Blvd.

February 12, 2024 EX-99.(E)(21)

SCIENCE 37 HOLDINGS, INC. Second Amended and Restated Executive Severance Policy

Exhibit (e)(21) SCIENCE 37 HOLDINGS, INC. Second Amended and Restated Executive Severance Policy I. Overview The Executive Severance Policy (the “Policy”) established by Science 37 Holdings, Inc. (the “Company”) and approved by the Company’s Board of Directors, effective as of October 7, 2021, amended and restated as of April 18, 2023, is hereby amended and restated as set forth herein as the Poli

February 12, 2024 EX-99.(A)(1)(F)

This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below). The Offer (as defined below) is made solely pursuant to the Offer to Purchase (as defined below), the related Letter of Transmittal, a

Exhibit (a)(1)(F) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below).

February 12, 2024 SC TO-T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer)) MARLIN M

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer)) MARLIN MERGER SUB CORPORATION a wholly-owned subsidiary of eMED, LLC (Name of Filing Persons (Offerors)) Common Stock, $0.0001 Par Value (Title of Class of Se

February 12, 2024 EX-99.(E)(3)

eMed, LLC 990 Biscayne Blvd. Suite 1501 Miami, FL 33132

Exhibit (e)(3) eMed, LLC 990 Biscayne Blvd. Suite 1501 Miami, FL 33132 December 20, 2023 Confidential Science 37 Holdings, Inc. 800 Park Offices Drive Suite 3606 Research Triangle Park, NC 27709 Re: Proposed Transaction Ladies and Gentlemen: This letter agreement (this “Letter Agreement”) is entered into by (i) eMed, LLC (“eMed”), and (ii) Science 37 Holdings, Inc. (“Science 37”). Each of eMed and

February 12, 2024 EX-99.(A)(1)(C)

Offer to Purchase for Cash All Outstanding Shares of Common Stock Science 37 Holdings, Inc. at $5.75 Net Per Share in Cash Pursuant to the Offer to Purchase Dated February 12, 2024 by Marlin Merger Sub Corporation A wholly-owned subsidiary of eMed, L

 Exhibit (a)(1)(C) Offer to Purchase for Cash All Outstanding Shares of Common Stock of Science 37 Holdings, Inc.

February 12, 2024 SC 14D9

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 Science 37 Holdings, Inc. (Name of Subject Company) Science 37

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 Science 37 Holdings, Inc. (Name of Subject Company) Science 37 Holdings, Inc. (Name of Persons Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644207

February 12, 2024 EX-99.(A)(1)(D)

Offer to Purchase for Cash All Outstanding Shares of Common Stock Science 37 Holdings, Inc. at $5.75 Net Per Share in Cash Pursuant to the Offer to Purchase Dated February 12, 2024 Marlin Merger Sub Corporation a wholly-owned subsidiary of eMed, LLC

 Exhibit (a)(1)(D) Offer to Purchase for Cash All Outstanding Shares of Common Stock of Science 37 Holdings, Inc.

February 12, 2024 EX-99.(E)(20)

February 20, 2020

Exhibit (e)(20) 12121 Bluff Creek Drive, Suite 100 Los Angeles, CA 90094 Phone: 984.

February 12, 2024 EX-99.(A)(1)(E)

Notice of Guaranteed Delivery for Offer to Purchase for Cash All Outstanding Shares of Common Stock of Science 37 Holdings, Inc. at $5.75 Net Per Share in Cash Pursuant to the Offer to Purchase Dated February 12, 2024 by Marlin Merger Sub Corporation

 Exhibit (a)(1)(E) Notice of Guaranteed Delivery for Offer to Purchase for Cash All Outstanding Shares of Common Stock of Science 37 Holdings, Inc.

February 9, 2024 8-K

Costs Associated with Exit or Disposal Activities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 7, 2024 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commiss

February 9, 2024 SC14D9C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 Science 37 Holdings, Inc. (Name of Subject Company) Science 37

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 Science 37 Holdings, Inc. (Name of Subject Company) Science 37 Holdings, Inc. (Name of Persons Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644207 (CUSIP Number of

January 31, 2024 SC 13D/A

Redmile Group, LLC - SC 13D/A

SC 13D/A 1 tm244726d1sc13da.htm SC 13D/A UNITED STATES SECURITIES & EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Science 37 Holdings, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 808644207 (CUSIP Number) Redmile Group, LLC Attn: Jennifer Ciresi One Letterman Drive, Bldg D, Ste

January 29, 2024 EX-99.1

Science 37 to be Acquired by eMed, Expanding Access to Patients and Accelerating Enrollment Science 37 stockholders to receive $5.75 per share in cash

Exhibit 99.1 Science 37 to be Acquired by eMed, Expanding Access to Patients and Accelerating Enrollment Science 37 stockholders to receive $5.75 per share in cash Research Triangle Park, NC – January 29, 2024 – Science 37 Holdings, Inc. (Nasdaq: SNCE) (the “Company” or “Science 37”), the clinical research industry’s leading MetasiteTM, today announced that it has entered into a definitive merger

January 29, 2024 EX-10.3

TENDER AND SUPPORT AGREEMENT

Exhibit 10.3 TENDER AND SUPPORT AGREEMENT This TENDER AND SUPPORT AGREEMENT (this “Agreement”), dated as of January 28, 2024, is by and among eMED, LLC, a Delaware limited liability company (“Parent”), Marlin Merger Sub Corporation, a Delaware corporation and a wholly owned subsidiary of Parent (“Merger Sub”), and Pharmaceutical Product Development, LLC (the “Stockholder”). WHEREAS, as of the date

January 29, 2024 EX-99.5

Employee FAQs

Exhibit 99.5 Employee FAQs 1. What was announced regarding Science 37 and eMed? ● We recently announced that Science 37 (also referred to as “we,” “us,” “our” or the “Company”) has entered into a definitive merger agreement with eMed at $5.75 per share, a premium to our existing share price. ○ The strategic merger aims to combine eMed’s extensive access to patients and patient engagement technolog

January 29, 2024 EX-99.3

From: Science 37

Exhibit 99.3 From: Science 37 To: Science 37 Customers Date: January 29, 2024 Subject: Science 37 Update: Access to More Patients and Faster Enrollment Dear [INSERT CUSTOMER NAME], Your success is top priority as we continue to enhance our ability to access new patients and accelerate enrollment on your behalf. Today, we’re pleased to announce that Science 37 has entered into a merger agreement wi

January 29, 2024 EX-99.4

From: Science 37

Exhibit 99.4 From: Science 37 To: Science 37 Vendors Date: January 29, 2024 Subject: Company Update: A New Chapter in Science 37’s Journey Dear [Partner’s Name], Today, we’re pleased to announce that Science 37 has entered into a merger agreement with eMed, the leader in on-demand virtual care and treatment for consumers. You can see a copy of the press release HERE. eMed brings an extensive patie

January 29, 2024 EX-2.1

AGREEMENT AND PLAN OF MERGER by and among eMED, LLC MARLIN MERGER SUB CORPORATION SCIENCE 37 HOLDINGS, Inc. Dated as of January 28, 2024 Table of Contents

Exhibit 2.1 AGREEMENT AND PLAN OF MERGER by and among eMED, LLC MARLIN MERGER SUB CORPORATION and SCIENCE 37 HOLDINGS, Inc. Dated as of January 28, 2024 Table of Contents Page Article 1 THE OFFER AND THE MERGER 2 1.1 The Offer 2 1.2 Company Actions 5 1.3 The Merger 6 1.4 Closing and Effective Time of the Merger 7 Article 2 CONVERSION OF SECURITIES IN THE MERGER 7 2.1 Conversion of Securities 7 2.2

January 29, 2024 SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Science 37 Holdings, Inc. (Name of Subject Company (Issuer)) Marlin M

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Science 37 Holdings, Inc. (Name of Subject Company (Issuer)) Marlin Merger Sub Corporation a wholly owned subsidiary of eMed, LLC (Names of Filing Persons (Offerors)) Common Stock, $0.0001 par value per share (Title of

January 29, 2024 SC14D9C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 Science 37 Holdings, Inc. (Name of Subject Company) Science 37

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 Science 37 Holdings, Inc. (Name of Subject Company) Science 37 Holdings, Inc. (Name of Persons Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644207 (CUSIP Number of

January 29, 2024 EX-10.2

TENDER AND SUPPORT AGREEMENT

Exhibit 10.2 TENDER AND SUPPORT AGREEMENT This TENDER AND SUPPORT AGREEMENT (this “Agreement”), dated as of January 28, 2024, is by and among eMED, LLC, a Delaware limited liability company (“Parent”), Marlin Merger Sub Corporation, a Delaware corporation and a wholly owned subsidiary of Parent (“Merger Sub”), and the entities listed on Schedule I hereto (each, a “Stockholder”). WHEREAS, as of the

January 29, 2024 EX-99.6

Customer FAQs

Exhibit 99.6 Customer FAQs 1. What was announced regarding Science 37 and eMed? ● We recently announced that Science 37 (also referred to as “we,” “us,” “our” or the “Company”) has entered into a definitive merger agreement with eMed at $5.75 per share, a premium to our existing share price. ○ The strategic merger aims to combine eMed’s extensive access to patients and patient engagement technolog

January 29, 2024 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 28, 2024 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commiss

January 29, 2024 EX-99.1

Science 37 to be Acquired by eMed, Expanding Access to Patients and Accelerating Enrollment Science 37 stockholders to receive $5.75 per share in cash

Exhibit 99.1 Science 37 to be Acquired by eMed, Expanding Access to Patients and Accelerating Enrollment Science 37 stockholders to receive $5.75 per share in cash Research Triangle Park, NC – January 29, 2024 – Science 37 Holdings, Inc. (Nasdaq: SNCE) (the “Company” or “Science 37”), the clinical research industry’s leading MetasiteTM, today announced that it has entered into a definitive merger

January 29, 2024 EX-10.1

TENDER AND SUPPORT AGREEMENT

Exhibit 10.1 TENDER AND SUPPORT AGREEMENT This TENDER AND SUPPORT AGREEMENT (this “Agreement”), dated as of January 28, 2024, is by and among eMED, LLC, a Delaware limited liability company (“Parent”), Marlin Merger Sub Corporation, a Delaware corporation and a wholly owned subsidiary of Parent (“Merger Sub”), and [●] (the “Stockholder”). WHEREAS, as of the date hereof, the Stockholder is the bene

January 29, 2024 EX-10.4

TENDER AND SUPPORT AGREEMENT

Exhibit 10.4 TENDER AND SUPPORT AGREEMENT This TENDER AND SUPPORT AGREEMENT (this “Agreement”), dated as of January 28, 2024, is by and among eMED, LLC, a Delaware limited liability company (“Parent”), Marlin Merger Sub Corporation, a Delaware corporation and a wholly owned subsidiary of Parent (“Merger Sub”), and the entities listed on Schedule I hereto (each, a “Stockholder”). WHEREAS, as of the

January 29, 2024 EX-99.2

Subject: Science 37 to merge with consumer virtual care company eMed

Exhibit 99.2 Subject: Science 37 to merge with consumer virtual care company eMed Dear Squad, Today, we announced that Science 37 has entered into a merger agreement with eMed, the leader in on-demand virtual care and treatment for consumers. You can see a copy of the press release HERE. This strategic move is a positive step forward for Science 37 on our journey to transform clinical research whi

December 22, 2023 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 22, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commis

December 5, 2023 EX-3.1

CERTIFICATE OF AMENDMENT TO THE SECOND AMENDED AND RESTATED CERTIFICATE OF INCORPORATION SCIENCE 37 HOLDINGS, INC.

Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE SECOND AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF SCIENCE 37 HOLDINGS, INC. Science 37 Holdings, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”), hereby certifies as follows: 1. The name of the Corporation is Science 37 Holdings, Inc. The Corporation was

December 5, 2023 8-K

Regulation FD Disclosure, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 5, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commiss

December 5, 2023 EX-99.1

Science 37 Holdings, Inc. Announces 1-for-20 Reverse Stock Split effective December 8, 2023

Exhibit 99.1 NEWS RELEASE Science 37 Holdings, Inc. Announces 1-for-20 Reverse Stock Split effective December 8, 2023 RESEARCH TRIANGLE PARK, N.C., December 5, 2023—Science 37 Holdings, Inc. (Nasdaq: SNCE) (“Science 37” or the “Company”), the clinical research industry-leading Metasite™, announced today that it will effect a 1-for-20 reverse stock split (“Reverse Stock Split”) of its outstanding c

November 29, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 29, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commis

November 7, 2023 EX-99.1

SCIENCE 37 HOLDINGS, INC. POLICY FOR THE RECOVERY OF ERRONEOUSLY AWARDED COMPENSATION

SCIENCE 37 HOLDINGS, INC. POLICY FOR THE RECOVERY OF ERRONEOUSLY AWARDED COMPENSATION A. OVERVIEW In accordance with the applicable rules of The Nasdaq Stock Market (the “Nasdaq Rules”), Section 10D of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) and Rule 10D-1 promulgated thereunder (“Rule 10D-1”), the Board of Directors (the “Board”) of Science 37 Holdings, Inc. (the “Com

November 7, 2023 EX-99.1

Science 37 Reports Third Quarter 2023 Financial Results

Exhibit 99.1 NEWS RELEASE Science 37 Reports Third Quarter 2023 Financial Results Research Triangle Park, N.C., November 7, 2023 — Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”), the industry-leading Metasite™, today reported its financial results for the quarter ended September 30, 2023. “Our third quarter results were highlighted by continued quarterly improvements in our key profitabi

November 7, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 7, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commiss

November 7, 2023 EX-10.2+

SCIENCE 37 HOLDINGS, INC. AMENDED AND RESTATED 2022 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN

SCIENCE 37 HOLDINGS, INC. AMENDED AND RESTATED 2022 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN ARTICLE I. PURPOSE The Plan was established effective as of November 9, 2022, the date of its original approval by the Board, and was amended and restated as of November 1, 2023. The Plan’s purpose is to enhance the Company’s ability to attract, retain and motivate persons who are expected to make import

November 7, 2023 EX-10.1+

SCIENCE 37 HOLDINGS, INC. 2021 INCENTIVE AWARD PLAN RESTRICTED STOCK UNIT GRANT NOTICE

SCIENCE 37 HOLDINGS, INC. 2021 INCENTIVE AWARD PLAN RESTRICTED STOCK UNIT GRANT NOTICE Science 37 Holdings, Inc., a Delaware corporation (the “Company”), has granted to the participant listed below (“Participant”) the Restricted Stock Units (the “RSUs”) described in this Restricted Stock Unit Grant Notice (this “Grant Notice”), subject to the terms and conditions of the Science 37 Holdings, Inc. 2

November 7, 2023 S-8

As filed with the Securities and Exchange Commission on November 7, 2023

As filed with the Securities and Exchange Commission on November 7, 2023 Registration No.

November 7, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 7, 2023 EX-FILING FEES

Calculation of Filing Fee Tables Form S-8 (Form Type) SCIENCE 37 HOLDINGS, INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) SCIENCE 37 HOLDINGS, INC.

October 27, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

October 3, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

August 8, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001

August 8, 2023 EX-99.1

Science 37 Reports Second Quarter 2023 Financial Results

Exhibit 99.1 NEWS RELEASE Science 37 Reports Second Quarter 2023 Financial Results Research Triangle Park, N.C., August 8, 2023 — Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”), the industry-leading Metasite™, today reported its financial results for the quarter ended June 30, 2023. “The actions we have taken over the past nine months are leading to meaningful improvements as evidenced b

August 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 8, 2023 SCIENCE 37 HOLDING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 8, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commissio

June 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 27, 2023 SCIENCE 37 HOLDINGS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 27, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commission

May 15, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 00

May 15, 2023 EX-10.1+

Science 37 Holdings, Inc. Amended and Restated Executive Severance Policy

EX-10.1+ 2 ex101amendedandrestatedexe.htm EX-10.1+ SCIENCE 37 HOLDINGS, INC. Amended and Restated Executive Severance Policy I.OVERVIEW The Executive Severance Policy (the “Policy”) established by Science 37 Holdings, Inc. (the “Company”) and approved by the Company’s Board of Directors, effective as of October 7, 2021 is hereby amended and restated as set forth herein as the Policy, effective as

May 15, 2023 EX-10.2+

Participation Agreement for the Amended and Restated Executive Severance Policy

[Date] [Name] [Title] Re: Participation Agreement for Science 37 Holdings, Inc.’s Amended and Restated Executive Severance Plan Dear [Name], The Compensation Committee (the “Committee”) of the Board of Directors (the “Board”) of Science 37 Holdings, Inc. (the “Company”) hereby extends to you (and with respect to the Company’s Chief Executive Officer, the Board hereby extends to you) the opportunit

May 15, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 15, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commission

May 15, 2023 EX-99.1

Science 37 Reports First Quarter 2023 Financial Results

Exhibit 99.1 NEWS RELEASE Science 37 Reports First Quarter 2023 Financial Results Research Triangle Park, N.C., May 15, 2023 — Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”), the industry-leading Metasite™, today reported its financial results for the quarter ended March 31, 2023. "First quarter results reflected continued progress with our key strategic initiatives,” stated David Coman,

May 11, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 11, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commission

May 2, 2023 SC TO-I/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Amendment No. 3) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Amendment No. 3) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer) and Filing Person (Offeror)) Stock Options to Purchase Common Stock, Par Value $0.0001 Per Share (Title of Class of Securities) 808644108 (CU

May 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 28, 2023 SCIENCE 37 HOLDING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 28, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commissio

April 19, 2023 SC TO-I/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Amendment No. 2) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company

SC TO-I/A 1 tm2310996d4sctoia.htm SC TO-I/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Amendment No. 2) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer) and Filing Person (Offeror)) Stock Options to Purchase Common Stock, Par Value $0.0001 Per Share

April 19, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 13, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commissio

April 11, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 11, 2023 SCIENCE 37 HOLDING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 11, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commissio

April 11, 2023 SC TO-I/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Amendment No. 1) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Amendment No. 1) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer) and Filing Person (Offeror)) Stock Options to Purchase Common Stock, Par Value $0.0001 Per Share (Title of Class of Securities) 808644108 (CU

April 11, 2023 EX-99.1

Science 37 Unveils Three Global Centers of Excellence to Drive Efficiency, Speed and Quality Centers of Excellence to strengthen and scale the company’s Metasite offering and accelerate its path to profitability

Exhibit 99.1 NEWS RELEASE Science 37 Unveils Three Global Centers of Excellence to Drive Efficiency, Speed and Quality Centers of Excellence to strengthen and scale the company’s Metasite offering and accelerate its path to profitability RESEARCH TRIANGLE PARK, N.C., April 11, 2023—Science 37 Holdings, Inc. (Nasdaq: SNCE), the industry-leading MetasiteTM, today unveiled three global Centers of Exc

April 3, 2023 EX-99.(A)(1)(K)

Exchange Offer FAQs.

Exhibit (a)(1)(K) Science 37 Holdings, Inc. Frequently Asked Questions About Offer to Exchange Eligible Options for Restricted Stock Units What is the Offer to Exchange Eligible Options for Restricted Stock Units? Since becoming public in October 2021, we have experienced a significant decline in our stock price. As a result, some of our employees and other service providers hold “underwater” stoc

April 3, 2023 EX-99.(A)(1)(D)

Form of Confirmation Email.

Exhibit (a)(1)(D) FORM OF CONFIRMATION EMAIL TO ELIGIBLE PARTICIPANTS From: awardchoice@aon.

April 3, 2023 EX-99.(A)(1)(E)

Form of Reminder Email.

Exhibit (a)(1)(E) FORM OF REMINDER EMAIL Subject: Science 37 Holdings, Inc. – Exchange Offer Election Reminder To: Date: SCIENCE 37 HOLDINGS, INC. EXCHANGE OFFER Our records show you have not made an election to participate in Science 37 Holdings, Inc.’s Offer to Exchange Eligible Options for Restricted Stock Units (the “Exchange Offer”). This email is to remind you that April 28, 2023 at 11:59 p.

April 3, 2023 EX-99.(A)(1)(I)

Informational Presentation to Eligible Participants.

Stock Option Exchange Program April 3, 2023 Exhibit (a)(1)(I) Agenda • Stock Option Exchange Overview • Stock Option Eligibility • Exchange Details • Taxation Considerations • Example of Exchanges 2 Exchange Overview RSU refresher Stock Option Exchange Overview • Stock Options have been a key component of our long-term incentive program.

April 3, 2023 SC TO-I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer) and Filin

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SCIENCE 37 HOLDINGS, INC. (Name of Subject Company (Issuer) and Filing Person (Offeror)) Stock Options to Purchase Common Stock, Par Value $0.0001 Per Share (Title of Class of Securities) 808644108 (CUSIP Number of Clas

April 3, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Table Schedule TO-I (Form Type) Science 37 Holdings, Inc.

April 3, 2023 EX-99.(A)(1)(H)

Screenshots from the Exchange Offer Website.

Exhibit (a)(1)(H)

April 3, 2023 EX-99.(A)(1)(G)

Form of Notice of Expiration of Exchange Offer Email.

Exhibit (a)(1)(G) FORM OF NOTICE OF EXPIRATION OF EXCHANGE OFFER To: Eligible Participants Date: May 1, 2023 Subject: Expiration of Exchange Offer SCIENCE 37 HOLDINGS, INC.

April 3, 2023 EX-99.(A)(1)(A)

Offer to Exchange Eligible Options for Restricted Stock Units, dated April 3, 2023.

Exhibit (a)(1)(A) SCIENCE 37 HOLDINGS, INC. 800 PARK OFFICES DRIVE, SUITE 3606 RESEARCH TRIANGLE PARK, NORTH CAROLINA 27709 OFFER TO EXCHANGE ELIGIBLE OPTIONS FOR RESTRICTED STOCK UNITS This document constitutes part of the prospectus relating to the securities that have been registered under the Securities Act of 1933, as amended. The prospectus relates to the 2015 Stock Plan and the 2021 Incenti

April 3, 2023 EX-99.(A)(1)(C)

Election Form on the Exchange Offer Website.

Exhibit (a)(1)(C)

April 3, 2023 EX-99.(A)(1)(J)

Script of the Option Exchange Presentation to Eligible Participants.

Exhibit (a)(1)(J) Speakers: Christine Pellizzari, Susan Eylward and Joe Fagan April 3, 2023 Exchange Offer Script (SLIDE 1) Hello, as you all know, I am Christine Pellizzari, Chief Legal and Human Resources Officer, and joining me today are Susan Eylward, Senior Corporate Counsel, and Joe Fagan our Director of Global Equity Compensation, and we are going to walk everyone through the stock option exchange offer.

April 3, 2023 EX-99.(D)(2)

Form of Option Agreement under 2015 Stock Plan.

Exhibit (d)(2) Science 37, Inc. 2015 Stock Plan Notice Of Stock Option Grant (Installment Exercise) The Optionee has been granted the following option to purchase shares of the Common Stock of Science 37, Inc.: Name of Optionee: [] Total Number of Shares: [] Type of Option: [] Exercise Price per Share: $[] Date of Grant: [] Date Exercisable: [] Vesting Commencement Date: [] Expiration Date: []. Th

April 3, 2023 EX-99.(A)(1)(F)

Form of Final Reminder Email.

Exhibit (a)(1)(F) FORM OF FINAL REMINDER EMAIL Subject: Science 37 Holdings, Inc. – Exchange Offer Final Deadline To: Date: April 28, 2023 SCIENCE 37 HOLDINGS, INC. EXCHANGE OFFER This email is to remind you that today, April 28, 2023 at 11:59 p.m. Eastern Time is the final deadline to make an election to participate in Science 37 Holdings, Inc.’s Offer to Exchange Eligible Options for Restricted

April 3, 2023 EX-99.(A)(1)(B)

Form of Announcement Email to Eligible Participants.

Exhibit (a)(1)(B) FORM OF ANNOUNCEMENT EMAIL TO ELIGIBLE PARTICIPANTS Subject: Science 37 Holdings, Inc.

April 3, 2023 EX-99.(A)(1)(L)

Form of Restricted Stock Unit Agreement under the 2021 Incentive Award Plan.

Exhibit (a)(1)(L) SCIENCE 37 HOLDINGS, INC. 2021 INCENTIVE AWARD PLAN RESTRICTED STOCK UNIT GRANT NOTICE Science 37 Holdings, Inc., a Delaware corporation (the “Company”), has granted to the participant listed below (“Participant”) the Restricted Stock Units (the “RSUs”) described in this Restricted Stock Unit Grant Notice (this “Grant Notice”), subject to the terms and conditions of the Science 3

March 20, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

March 20, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

March 13, 2023 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 13, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commissio

March 10, 2023 CORRESP

March 10, 2023

March 10, 2023 VIA EDGAR SUBMISSION U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Science 37 Holdings, Inc. (the “Company”) Registration Statement on Form S-3 (File No. 333-270285) (the “Registration Statement”) Dear Ladies and Gentlemen: Pursuant to Rule 461 of the Securities Act of 1933, as amended (the “Securities Act”), th

March 9, 2023 424B3

Science 37 Holdings, Inc. 103,576,231 Shares of Common Stock

424B3 1 tm239025-1424b3.htm 424B3 Filed Pursuant to Rule 424(b)(3) Registration No. 333-260828 PROSPECTUS Science 37 Holdings, Inc. 103,576,231 Shares of Common Stock This prospectus relates to the offer and sale from time to time by the selling securityholders named in this prospectus (the “Selling Securityholders”) of up to 103,576,231 shares of common stock, par value $0.0001 per share (the “co

March 6, 2023 EX-4.4

Form of Indenture.

Exhibit 4.4 SCIENCE 37 HOLDINGS, INC. Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [●], 20 Debt Securities Table Of Contents Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee’s Certificate 8 Se

March 6, 2023 EX-10.11

Form of Option Agreement under 2022 Employment Inducement Incentive Award Plan

[Signature Page to Stock Option Grant Notice] SCIENCE 37 HOLDINGS, INC. 2022 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN STOCK OPTION GRANT NOTICE Science 37 Holdings, Inc., a Delaware corporation (the “Company”) has granted to the participant listed below (“Participant”) the stock option (the “Option”) described in this Stock Option Grant Notice (this “Grant Notice”), subject to the terms and cond

March 6, 2023 EX-21.1

Subsidiaries of the Company.

Exhibit 21.1 Subsidiaries of Science 37 Holdings, Inc. Jurisdiction of Name of Subsidiary Organization Science 37, Inc. Delaware Diversity in Clinical Research Foundation Delaware Science 37 s.r.o Slovak Republic Science 37 UK Limited England and Wales

March 6, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-39727 SCIENCE

March 6, 2023 EX-10.10

2022 Employment Inducement Incentive Award Plan

snce-2022inducementplan SCIENCE 37 HOLDINGS, INC. 2022 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN ARTICLE I. PURPOSE The Plan’s purpose is to enhance the Company’s ability to attract, retain and motivate persons who are expected to make important contributions to the Company by providing these individuals with equity ownership opportunities and/or equity-linked compensatory opportunities. Capitali

March 6, 2023 S-3

As filed with the Securities and Exchange Commission on March 6, 2023

As filed with the Securities and Exchange Commission on March 6, 2023 Registration No.

March 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 6, 2023 SCIENCE 37 HOLDINGS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 6, 2023 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commission

March 6, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Science 37 Holdings, Inc.

March 6, 2023 EX-10.12

Form of Restricted Stock Unit Agreement under 2022 Employment Inducement Incentive Award Plan

snce-formofrsuagreementi [Signature Page to Restricted Stock Unit Grant Notice] SCIENCE 37 HOLDINGS, INC.

March 6, 2023 EX-10.6

Offer Letter by and between Science 37, Inc. and Darcy Forman, dated November 3, 2019.

March 6, 2023 EX-24.2

Power of Attorney of Paul von Autenried

Exhibit 24.2 POWER OF ATTORNEY The undersigned hereby constitutes and appoints David Coman and Mike Zaranek, and each of them singly (with full power to each of them to act alone), his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them, for him and in his name, place and stead, and in any and all capacities, to sign any and all amendmen

March 6, 2023 CORRESP

March 6, 2023

CORRESP 1 filename1.htm March 6, 2023 Via EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F. Street, N.E. Washington, D.C. 20549 Re: Science 37 Holdings, Inc. – Registration Statement on Form S-3 Ladies and Gentlemen, Attached please find the Registration Statement on Form S-3 filed by Science 37 Holdings, Inc. (the “Company”) in connection with “shelf” r

March 6, 2023 EX-99.1

Science 37 Reports Fourth Quarter and Full Year 2022 Financial Results

Exhibit 99.1 NEWS RELEASE Science 37 Reports Fourth Quarter and Full Year 2022 Financial Results Research Triangle Park, N.C., March 6, 2023 — Science 37 Holdings, Inc. (Nasdaq: SNCE), (“Science 37”), the industry-leading Metasite™, today reported its financial results for the quarter and full year ended December 31, 2022. “Fourth quarter results demonstrated a healthy rebound in bookings and cont

March 6, 2023 POS AM

As filed with the Securities and Exchange Commission on March 6, 2023

As filed with the Securities and Exchange Commission on March 6, 2023 Registration No.

December 30, 2022 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 27, 2022 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commis

December 30, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

424B3 1 a424b3no12filing.htm 424B3 Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 12 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 12 (the “Prospectus Supplement”) updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the “Company,” “we,” “us,” and “our”), dated April 20, 2022 (t

November 10, 2022 S-8

 As filed with the Securities and Exchange Commission on November 10, 2022

?As filed with the Securities and Exchange Commission on November 10, 2022 Registration No.

November 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 10, 2022 EX-10.2

Severance Agreement and General Release between Steve Geffon and Science 37, Inc dated September 26, 2022.

1 CONFIDENTIAL SEVERANCE AGREEMENT AND GENERAL RELEASE FOR EXECUTIVE LEVEL EMPLOYEES This Confidential Severance Agreement and General Release for Executive Level Employees (?Agreement?) is made by and between Steve Geffon (?Employee?) and Science 37, Inc.

November 10, 2022 EX-99.1

Science 37 Holdings, Inc. 2022 Employment Inducement Incentive Award Plan

Exhibit?99.1 SCIENCE 37 HOLDINGS,?INC. 2022 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN ARTICLE?I. Purpose ? The Plan?s purpose is to enhance the Company?s ability to attract, retain and motivate persons who are expected to make important contributions to the Company by providing these individuals with equity ownership opportunities and/or equity-linked compensatory opportunities. Capitalized terms

November 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 10, 2022 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commis

November 10, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 11 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 11 (the "Prospectus Supplement") updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated April 20, 2022 (the ?Prospectus?), which forms a par

November 10, 2022 EX-99.1

Science 37 Reports Third Quarter 2022 Financial Results

Exhibit 99.1 NEWS RELEASE Science 37 Reports Third Quarter 2022 Financial Results Research Triangle Park, N.C., November 10, 2022 ? Science 37 Holdings, Inc. (Nasdaq: SNCE), (?Science 37?) the Agile Clinical Trial Operating SystemTM, today reported its financial results for the quarter ended September 30, 2022. ?The third quarter was challenging from a bookings perspective as we experienced delays

November 10, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Tables S-8 (Form Type) SCIENCE 37 HOLDINGS, INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock reserved for

November 10, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 10 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 10 (the "Prospectus Supplement") updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated April 20, 2022 (the ?Prospectus?), which forms a par

October 5, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 9 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 9 (the ?Prospectus Supplement?) updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated April 20, 2022 (the ?Prospectus?), which forms a part

October 5, 2022 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 29, 2022 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commi

October 5, 2022 EX-99.1

Science 37 appoints Paul von Autenried to its Board of Directors Former Chief Information officer and Executive Committee member for Bristol Myers Squibb brings deep industry and technology expertise to Science 37.

Exhibit 99.1 NEWS RELEASE Science 37 appoints Paul von Autenried to its Board of Directors Former Chief Information officer and Executive Committee member for Bristol Myers Squibb brings deep industry and technology expertise to Science 37. RESEARCH TRIANGLE PARK. October 5, 2022?Science 37 Holdings, Inc. (Nasdaq: SNCE), the Agile Clinical Trial Operating System?, today announced the appointment o

September 30, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 30, 2022 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commi

September 30, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 8 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 8 (the “Prospectus Supplement”) updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the “Company,” “we,” “us,” and “our”), dated April 20, 2022 (the “Prospectus”), which forms a part

September 12, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 7 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 7 (the ?Prospectus Supplement?) updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated April 20, 2022 (the ?Prospectus?), which forms a part

September 12, 2022 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 9, 2022 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commis

September 12, 2022 EX-99.1

Science 37 Names Industry Veteran Michael Shipton as Chief Commercial Officer Shipton joins Science 37 to help capitalize on the high demand for decentralized clinical trials and drive further growth into enterprise opportunities.

Exhibit 99.1 NEWS RELEASE Science 37 Names Industry Veteran Michael Shipton as Chief Commercial Officer Shipton joins Science 37 to help capitalize on the high demand for decentralized clinical trials and drive further growth into enterprise opportunities. RESEARCH TRIANGLE PARK. September 12, 2022?Science 37 Holdings, Inc. (Nasdaq: SNCE), the Agile Clinical Trial Operating System?, today announce

September 12, 2022 EX-10.1

mployment Agreement, effective September 12, 2022, between Michael Shipton and Science 37, Inc.

EXHIBIT 10.1 EXECUTIVE EMPLOYMENT AGREEMENT This EXECUTIVE EMPLOYMENT AGREEMENT (the "Agreement') is entered into and effective as of September 12, 2022 (the "Effective Date"), by and between Michael Shipton (the "Executive") and Science 37, Inc. (the "Company"). Each of the Company and Executive are a "Party" and, collectively, they are the "Parties." RECITALS WHEREAS, the Company desires to empl

August 11, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 5 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 5 (the ?Prospectus Supplement?) updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated April 20, 2022 (the ?Prospectus?), which forms a part

August 11, 2022 EX-99.1

Science 37 Reports Second Quarter 2022 Financial Results

Exhibit 99.1 NEWS RELEASE Science 37 Reports Second Quarter 2022 Financial Results Research Triangle Park, N.C., August 11, 2022 ? Science 37 Holdings, Inc. (Nasdaq: SNCE), (?Science 37?) the Agile Clinical Trial Operating SystemTM, today reported its financial results for the quarter ended June 30, 2022. "We made meaningful strides across our strategic priorities in the second quarter and our pat

August 11, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 11, 2022 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commissi

August 11, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

424B3 1 a06302022424b3prospectussu.htm 424B3 Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 6 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 6 (the "Prospectus Supplement") updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the “Company,” “we,” “us,” and “our”), dated April 20,

August 11, 2022 S-8

 As filed with the Securities and Exchange Commission on August 11, 2022

S-8 1 tm2223086d2s8.htm FORM S-8  As filed with the Securities and Exchange Commission on August 11, 2022 Registration No. 333-  UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549   FORM S-8 REGISTRATION STATEMENT  Under THE SECURITIES ACT OF 1933 Science 37 Holdings, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware (State or other jurisdiction of incorpora

August 11, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001

August 11, 2022 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables S-8 (Form Type) SCIENCE 37 HOLDINGS, INC.

June 15, 2022 EX-99.1

Joint Filing Agreement

Exhibit 99.1 Joint Filing Agreement In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the ?Exchange Act?), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13D (including any and all amendments thereto, the ?Schedule 13D?) relating to the common stock, $0.0001 par value per share, of Science 37 Holdings,

June 15, 2022 SC 13D/A

LSAQ / Lifesci Acquisition II Corp / Redmile Group, LLC - SC 13D/A Activist Investment

SC 13D/A 1 tm2218489d1sc13da.htm SC 13D/A UNITED STATES SECURITIES & EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Science 37 Holdings, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 808644108 (CUSIP Number) Redmile Group, LLC Attn: Jennifer Ciresi One Letterman Drive, Bldg D, Ste

May 19, 2022 424B3

SCIENCE 37 HOLDINGS, INC. 103,576,231 Shares of Common Stock

Prospectus Supplement No. 4 Filed Pursuant to Rule 424(b)(3) (to Prospectus dated April 20, 2022) Registration No. 333-260828 SCIENCE 37 HOLDINGS, INC. 103,576,231 Shares of Common Stock This Prospectus Supplement No. 4 (this ?prospectus supplement?) updates, amends and supplements the prospectus of Science 37 Holdings, Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated April 20, 2022 (as previous

May 13, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 13, 2022 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commission

May 13, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 3 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 3 (the ?Prospectus Supplement?) updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated April 20, 2022 (the ?Prospectus?), which forms a part

May 9, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 1 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 1 (the ?Prospectus Supplement?) updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated April 20, 2022 (the ?Prospectus?), which forms a part

May 9, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 2 (To Prospectus dated April 20, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 2 (the "Prospectus Supplement") updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated April 20, 2022 (the ?Prospectus?), which forms a part

May 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 00

May 9, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 9, 2022 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commission F

May 9, 2022 EX-99.1

Science 37 Reports First Quarter 2022 Financial Results

Exhibit 99.1 NEWS RELEASE Science 37 Reports First Quarter 2022 Financial Results Research Triangle Park, N.C., May 9, 2022 ? Science 37 Holdings, Inc. (Nasdaq: SNCE), (?Science 37?) the Agile Clinical Trial Operating SystemTM, today reported its financial results for the quarter ended March 31, 2022. "The first quarter of 2022 was marked by continued execution across all of our strategic prioriti

May 4, 2022 424B3

Science 37 Holdings, Inc. 103,576,231 Shares of Common Stock

TABLE OF CONTENTS ?Filed Pursuant to Rule 424(b)(3)? ?Registration No. 333-260828? P R O S P E C T U S Science 37 Holdings, Inc. 103,576,231 Shares of Common Stock ? This prospectus relates to the offer and sale from time to time by the selling securityholders named in this prospectus (the ?Selling Securityholders?) of up to 103,576,231 shares of common stock, par value $0.0001 per share, consisti

April 27, 2022 424B3

Subject to Completion, dated April 8, 2022

TABLE OF CONTENTS The information in this prospectus is not complete and may be changed.

April 8, 2022 POS AM

As filed with the Securities and Exchange Commission on April 8, 2022

Table of Contents As filed with the Securities and Exchange Commission on April 8, 2022 Registration No.

April 7, 2022 SC 13D/A

LSAQ / Lifesci Acquisition II Corp / Lux Capital Management, LLC - AMENDMENT NO. 1 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Science 37 Holdings, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644108 (CUSIP Number) Peter Hebert Lux Capital Management, LLC 920 Broadway, 11th Floor New York, NY 10010 (646) 475-4385 (Name, Addres

March 23, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

March 23, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than t

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

March 22, 2022 EX-21.1

Subsidiaries of the Company.

Exhibit 21.1 Subsidiaries of Science 37 Holdings, Inc. Jurisdiction of Name of Subsidiary Organization Science 37, Inc. Delaware Diversity in Clinical Research Foundation Delaware Science 37 s.r.o Slovak Republic Science 37 Switzerland GmbH Switzerland Science 37 UK Limited England and Wales

March 22, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 1 (To Prospectus dated January 25, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 1 updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated January 25, 2022 (the ?Prospectus?), which forms a part of our Registration Statem

March 22, 2022 EX-10.11

Employment Agreement by and between Science 37, Inc. and Christine Pellizzari, dated June 7, 2021.

March 22, 2022 424B3

SCIENCE 37 HOLDINGS, INC.

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-260828 Prospectus Supplement No. 2 (To Prospectus dated January 25, 2022) SCIENCE 37 HOLDINGS, INC. This Prospectus Supplement No. 2 updates, amends and supplements the prospectus of Science 37 Holdings Inc. (the ?Company,? ?we,? ?us,? and ?our?), dated January 25, 2022 (the ?Prospectus?), which forms a part of our Registration Statem

March 22, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 22, 2022 SCIENCE 37 HOLDINGS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commissio

March 22, 2022 POS AM

As filed with the Securities and Exchange Commission on March 22, 2022

? As filed with the Securities and Exchange Commission on March 22, 2022 Registration No.

March 22, 2022 EX-10.21

Science 37 Holdings, Inc. Executive Severance Policy

Exhibit 10.21 SCIENCE 37 HOLDINGS, INC. Executive Severance Policy I.OVERVIEW This Executive Severance Policy (the ?Policy?) has been established by Science 37 Holdings, Inc. (the ?Company?), effective as of October 7, 2021 (the ?Effective Date?). This Policy is an ?employee welfare benefit plan? (as defined in Section 3(1) of ERISA) and a ?top hat? welfare plan for a select group of management or

March 22, 2022 EX-99.1

Science 37 Reports Fourth Quarter and Full Year 2021 Financial Results

Exhibit 99.1 NEWS RELEASE Science 37 Reports Fourth Quarter and Full Year 2021 Financial Results Research Triangle Park, N.C., March 22, 2022 ? Science 37 Holdings, Inc. (Nasdaq: SNCE), (?Science 37?) the Agile Clinical Trial Operating SystemTM, today reported its financial results for the quarter and full year ended December 31, 2021. ?Our impressive financial performance in the fourth quarter an

March 22, 2022 EX-4.1

Exhibit 4.1

Exhibit 4.1 DESCRIPTION OF REGISTERED SECURITIES General The following description summarizes some of the terms of our Second Amended and Restated Certificate of Incorporation (the ?certificate of incorporation?) and the Amended and Restated Bylaws (the ?bylaws?) of Science 37 Holdings, Inc. and its subsidiaries (the ?Company,? ?we,? ?us,? and ?our?) and of the General Corporation Law of the State

March 22, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-39727 SCIENCE

February 14, 2022 EX-99.1

JOINT FILING AGREEMENT February 14, 2022

EXHIBIT 99.1 JOINT FILING AGREEMENT February 14, 2022 Pursuant to and in accordance with the Securities Exchange Act of 1934, as amended (the ?Act?), and the rules and regulations thereunder, each party hereto hereby agrees to the joint filing, on behalf of each of them, of any filing required by such party under Section 13 or Section 16 of the Act or any rule or regulation thereunder (including a

February 14, 2022 SC 13G/A

LSAQ / Lifesci Acquisition II Corp / Ikarian Capital, LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Science 37 Holdings, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644108 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate

February 14, 2022 SC 13G/A

LSAQ / Lifesci Acquisition II Corp / RTW INVESTMENTS, LP - SCIENCE 37 HOLDINGS, INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Science 37 Holdings, Inc. (formerly known as Lifesci Acquisition II Corp.) (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644108 (CUSIP Number) December 31, 2021 (Date of event which requires filing of this statement) Ch

February 10, 2022 424B3

Science 37 Holdings, Inc. 103,576,231 Shares of Common Stock

TABLE OF CONTENTS ?Filed Pursuant to Rule 424(b)(3)? ?Registration No. 333-260828? P R O S P E C T U S Science 37 Holdings, Inc. 103,576,231 Shares of Common Stock ? This prospectus relates to the offer and sale from time to time by the selling securityholders named in this prospectus (the ?Selling Securityholders?) of up to 103,576,231 shares of common stock, par value $0.0001 per share, consisti

February 10, 2022 S-8

 As filed with the Securities and Exchange Commission on February 9, 2022

?As filed with the Securities and Exchange Commission on February 9, 2022 Registration No.

February 10, 2022 EX-99.3

Science 37, Inc. 2015 Stock Plan (incorporated herein by reference to Exhibit 99.3 of the Company’s Registration Statement on Form S-8 (File No. 333-262610) filed on February 10, 2022).

Exhibit 99.3 Science 37, Inc. 2015 Stock Plan Adopted on September 8, 2015 TABLE OF CONTENTS Page SECTION 1. ESTABLISHMENT AND PURPOSE 1 SECTION 2. ADMINISTRATION 1 (a) Committees of the Board of Directors 1 (b) Authority of the Board of Directors 1 SECTION 3. ELIGIBILITY 1 (a) General Rule 1 (b) Ten-Percent Stockholders 1 SECTION 4. STOCK SUBJECT TO PLAN 2 (a) Basic Limitation 2 (b) Additional Sh

February 10, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables S-8 (Form Type) SCIENCE 37 HOLDINGS, INC.

February 10, 2022 EX-99.1

Science 37 Holdings, Inc. 2021 Incentive Award Plan (incorporated herein by reference to Exhibit 99.1 of the Company’s Registration Statement on Form S-8 (File No. 333-262610) filed on February 10, 2022).

Exhibit 99.1 SCIENCE 37 HOLDINGS, INC. 2021 INCENTIVE AWARD PLAN ARTICLE I. Purpose The Plan?s purpose is to enhance the Company?s ability to attract, retain and motivate persons who make (or are expected to make) important contributions to the Company by providing these individuals with equity ownership opportunities and/or equity-linked compensatory opportunities. Capitalized terms used in the P

February 10, 2022 EX-99.2

Science 37 Holdings, Inc. 2021 Employee Stock Purchase Plan.

Exhibit 99.2 SCIENCE 37 HOLDINGS, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN Article I. PURPOSE The purpose of this Plan is to assist Eligible Employees of the Company and its Designated Subsidiaries in acquiring a stock ownership interest in the Company. The Plan consists of two components: (i) the Section 423 Component and (ii) the Non-Section 423 Component. The Section 423 Component is intended to

January 21, 2022 CORRESP

January 21, 2022

CORRESP 1 filename1.htm January 21, 2022 Via EDGAR Transmission United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Science 37 Holdings, Inc. Registration Statement on Form S-1 Filed November 5, 2021 Registration No. 333-260828 Ladies and Gentlemen: In accordance with Rule 461 of Regulation C of the General Rules and Regula

January 20, 2022 S-1/A

As filed with the Securities and Exchange Commission on January 20, 2022

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on January 20, 2022 Registration No.

December 30, 2021 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 2

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 2 x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30, 2021 or ? TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-39727 SCIENCE 37 HOLDIN

December 27, 2021 S-1/A

As filed with the Securities and Exchange Commission on December 23, 2021

Table of Contents As filed with the Securities and Exchange Commission on December 23, 2021 Registration No.

December 20, 2021 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

December 20, 2021 8-K

Non-Reliance on Previously Issued Financial Statements or a Related Audit Report or Completed Interim Review

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 20, 2021 Science 37 Holdings, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commis

December 20, 2021 EX-99.1

JOINT FILING AGREEMENT PURSUANT TO RULE 13D-1(K)(1)

Exhibit A JOINT FILING AGREEMENT PURSUANT TO RULE 13D-1(K)(1) The undersigned acknowledge and agree that the Statement on Schedule 13D filed with the Securities and Exchange Commission on or about the date hereof with respect to the beneficial ownership by the undersigned of the shares of Common Stock, par value $0.

December 20, 2021 SC 13D

LSAQ / Lifesci Acquisition II Corp / Thermo Fisher Scientific Inc. Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* SCIENCE 37 HOLDINGS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644108 (CUSIP Number) Michael A. Boxer Senior Vice President, General Counsel and Secretary Thermo Fisher Scientific Inc. 168 Third Aven

November 15, 2021 EX-99.4

Management’s Discussion and Analysis of Financial Condition and Results of Operations

Exhibit 99.4 Management?s Discussion and Analysis of Financial Condition and Results of Operations You should read the following discussion and analysis of the Company?s financial condition and results of operations together with the ?Selected Historical Consolidated Financial Data? section of this proxy statement/prospectus and the Company?s audited consolidated financial statements and unaudited

November 15, 2021 EX-10.18

Sponsor Lock-up Agreement

Exhibit 10.18 SPONSOR LOCK-UP AGREEMENT THIS SPONSOR LOCK-UP AGREEMENT (this ?Agreement?) is dated as of May 6, 2021, by and between the undersigned (the ?Holder?) and LifeSci Acquisition II Corp., a Delaware corporation (?Parent?). Capitalized terms used and not otherwise defined herein shall have the meanings given such terms in the Merger Agreement (as defined below). BACKGROUND A. Parent, Life

November 15, 2021 8-K/A

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 AMENDMENT NO. 1 TO FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 6, 2021 Science 37 Holdings, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incor

November 15, 2021 EX-99.3

Science 37, Inc. Condensed Consolidated Balance Sheets

Exhibit 99.3 Condensed consolidated financial statements (unaudited) Science 37, Inc. For the Three and Nine Months Ended September 30, 2021 and 2020 Science 37, Inc. Condensed Consolidated Balance Sheets (unaudited) September 30, 2021 December 31, 2020 Assets Current assets: Cash and cash equivalents $ 7,996,362 $ 32,478,948 Restricted cash - 1,004,142 Accounts receivable, net (including amounts

November 15, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 ☐TRANSITION REPORT

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

November 15, 2021 EX-10.19

Science 37 Holders Support Agreement

Exhibit 10.19 May 6, 2021 LifeSci Acquisition II Corp. 250 W. 55th St., #3401 New York, NY 10019 Attention: Andrew McDonald Re: Support Agreement Ladies and Gentlemen: This letter (this ?Support Agreement?) is being delivered by each of those stockholders of Science 37, Inc., a Delaware corporation (the ?Company?), whose names appear on the signature pages of this Agreement (each, a ?Stockholder?

November 15, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 15, 2021 Science 37 Holdings, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commis

November 15, 2021 EX-99.2

UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

Exhibit 99.2 UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION Defined terms included below have the same meaning as terms defined and included elsewhere in Current Report on Form 8-K. The following unaudited pro forma condensed combined financial statements present the combination of the financial information of LSAQ and Science 37, adjusted to give effect to the Business Combination.

November 15, 2021 EX-4.3

Warrant Exchange Agreement between LSAQ and the Sponsor.

Exhibit 4.3 WARRANT EXCHANGE AGREEMENT This WARRANT EXCHANGE AGREEMENT dated as of October 6, 2021, is by and between LifeSci Acquisition II Corp. a Delaware corporation (the ?Company?) LifeSci Holdings LLC, a Delaware limited liability company (?Holder?). WHEREAS, on November 24, 2020, the Company entered into a Private Warrant Agreement (the ?Warrant Agreement?) by and between the Company and th

November 15, 2021 EX-99.1

Science 37 Reports Quarterly Financial Results for the Period Ended September 30, 2021

Exhibit 99.1 NEWS RELEASE Science 37 Reports Quarterly Financial Results for the Period Ended September 30, 2021 LOS ANGELES, November 15, 2021 ? Science 37 Holdings, Inc. (Nasdaq: SNCE), (?Science 37?) the Operating System for today?s more agile clinical trials, today reported its financial results for the quarter ended September 30, 2021. ?We are pleased to have delivered another quarter of stro

November 8, 2021 SC 13D/A

LSAQ / Lifesci Acquisition II Corp / PPD, Inc. - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCIENCE 37 HOLDINGS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644108 (CUSIP Number) Julia James PPD, Inc. 929 North Front Street Wilmington, North Carolina 28401 (910) 251-0081 (Name, Address and T

November 5, 2021 EX-10.17

Amended and Restated Registration Rights Agreement by and among LSAQ, the Company and certain stockholders.

Exhibit 10.17 AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT ? THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this ?Agreement?) is entered into as of the 6th day of October, 2021, by and among Science 37 Holdings, Inc., a Delaware corporation (f/k/a LifeSci Acquisition II Corp.) (the ?Company?), the equityholders designated as Sponsor Equityholders on Schedule A hereto (collectively,

November 5, 2021 EX-10.13

2021 Science 37 Holdings, Inc. Incentive Award Plan.

Exhibit 10.13 SCIENCE 37 HOLDINGS, INC. 2021 INCENTIVE AWARD PLAN ARTICLE I. PURPOSE The Plan?s purpose is to enhance the Company?s ability to attract, retain and motivate persons who make (or are expected to make) important contributions to the Company by providing these individuals with equity ownership opportunities and/or equity-linked compensatory opportunities. Capitalized terms used in the

November 5, 2021 EX-10.16

2021 Science 37 Holdings, Inc. Employee Stock Purchase Plan.

Exhibit 10.16 SCIENCE 37 HOLDINGS, INC. ? 2021 EMPLOYEE STOCK PURCHASE PLAN ARTICLE I. PURPOSE The purpose of this Plan is to assist Eligible Employees of the Company and its Designated Subsidiaries in acquiring a stock ownership interest in the Company. The Plan consists of two components: (i) the Section 423 Component and (ii) the Non-Section 423 Component. The Section 423 Component is intended

November 5, 2021 S-1

As filed with the Securities and Exchange Commission on November 5, 2021

Table of Contents ? As filed with the Securities and Exchange Commission on November 5, 2021 Registration No.

November 5, 2021 EX-3.1

Amended and Restated Certificate of Incorporation.

Exhibit 3.1 SECOND AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF LIFESCI ACQUISITION II CORP. ? LifeSci Acquisition II Corp. (the ?Corporation?), a corporation organized and existing under the General Corporation Law of the State of Delaware (the ?DGCL?), does hereby certify as follows: 1.The name of the Corporation is LifeSci Acquisition II Corp. The Corporation was incorporated under the

November 5, 2021 EX-10.20

Director Nomination Agreement, by and among LifeSci Acquisition II Corp., LifeSci Holdings LLC, Science 37, Inc. and the stockholders party thereto.

Exhibit 10.20 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? DIRECTOR NOMINATION AGREEMENT ? BY AND AMONG ? LIFESCI ACQUISITION II CORP., ? LIFESCI HOLDINGS LLC, ? SCIENCE 37, INC. ? AND ? THE STOCKHOLDERS PARTY HERETO ? Dated as of October 6, 2021 ? ? ? CONTENTS ? ? ? ? ? Page Article I. DEFINITIONS AND CONSTRUCTION 1 Section 1.01 Definitions 1 Section 1.02 Rules of Construction 4 Article II. CORPORATE GO

October 18, 2021 EX-99.B

Director Nomination Agreement, dated as of October 6, 2021, by and among LifeSci Acquisition II Corp., Pharmaceutical Product Development, LLC and certain other stockholders of the Issuer.

Exhibit B Execution Version DIRECTOR NOMINATION AGREEMENT BY AND AMONG LIFESCI ACQUISITION II CORP.

October 18, 2021 SC 13D

LSAQ / Lifesci Acquisition II Corp / Lux Capital Management, LLC - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 Science 37 Holdings, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644108 (CUSIP Number) Peter Hebert Lux Capital Management, LLC 920 Broadway, 11th Floor New York, NY 10010 (646) 475-4385 (Name, Address and Telephone Num

October 18, 2021 EX-1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT This Agreement will confirm the agreement by and among the undersigned that the Schedule 13D filed with the Securities and Exchange Commission on the date hereof with respect to the beneficial ownership by the undersigned of the Common Stock of Science 37 Holdings, Inc.

October 18, 2021 EX-99.A

Joint Filing Agreement by and among the Reporting Persons.

Exhibit A JOINT FILING AGREEMENT PURSUANT TO RULE 13D-1(K)(1) The undersigned acknowledge and agree that the Statement on Schedule 13D filed with the Securities and Exchange Commission on or about the date hereof with respect to the beneficial ownership by the undersigned of the shares of Common Stock, par value $0.

October 18, 2021 SC 13D

LSAQ / Lifesci Acquisition II Corp / Redmile Group, LLC - SC 13D Activist Investment

UNITED STATES SECURITIES & EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Science 37 Holdings, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 808644108 (CUSIP Number) Redmile Group, LLC Jeremy C. Green One Letterman Drive, Bldg D, Ste D3-300 San Francisco, CA 94129 Attention: Legal

October 18, 2021 SC 13D

LSAQ / Lifesci Acquisition II Corp / PPD, Inc. - SC 13D Activist Investment

SC 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* SCIENCE 37 HOLDINGS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 808644108 (CUSIP Number) Julia James PPD, Inc. 929 North Front Street Wilmington, North Carolina 28401 (910) 251-0081 (Name, Address

October 18, 2021 EX-99.C

Amended and Restated Registration Rights Agreement, dated as of October 6, 2021, by and among the Issuer, Pharmaceutical Product Development, LLC and certain other stockholders of the Issuer.

EX-99.C 4 d244495dex99c.htm EX-C Exhibit C Execution Version AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is entered into as of the 6th day of October, 2021, by and among Science 37 Holdings, Inc., a Delaware corporation (f/k/a LifeSci Acquisition II Corp.) (the “Company”), the equityholders designated as Sponsor Equi

October 18, 2021 EX-99.1

Joint Filing Agreement, dated as of October 18, 2021, by and among Redmile Group, LLC, Jeremy C. Green and Redmile Private Investments II, L.P.

Exhibit 99.1 Joint Filing Agreement In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the ?Exchange Act?), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13D (including any and all amendments thereto, the ?Schedule 13D?) relating to the common stock, $0.0001 par value per share, of Science 37 Holdings,

October 15, 2021 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto) with respect to the common stock, $0.

October 15, 2021 SC 13G

LSAQ / Lifesci Acquisition II Corp / LifeSci Holdings LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO §240.13d-2 Science 37 Holdings, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 808644108 (CUSIP Number) October 6, 2021 (Date of Event

October 13, 2021 EX-3.3

Amended and Restated Bylaws of Science 37 Holdings, Inc.

Exhibit 3.3 Amended and Restated Bylaws of Science 37 Holdings, Inc. (a Delaware corporation) Table of Contents Page Article I - Corporate Offices 1 1.1 Registered Office 1 1.2 Other Offices 1 Article II - Meetings of Stockholders 1 2.1 Place of Meetings 1 2.2 Annual Meeting 1 2.3 Special Meeting 1 2.4 Notice of Business to be Brought before a Meeting. 2 2.5 Notice of Nominations for Election to t

October 13, 2021 EX-4.1

Specimen Stock Certificate of Science 37 Holdings, Inc.

Exhibit 4.1 NUMBER C- SHARES SEE REVERSE FOR CERTAIN DEFINITIONS CUSIP Science 37 Holdings, Inc. INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE This Certifies that is the owner of FULLY PAID AND NON-ASSESSABLE SHARES OF THE PAR VALUE OF $0.0001 EACH OF THE COMMON STOCK OF Science 37 Holdings, Inc. (THE ?COMPANY?) transferable on the books of the Company in person or by duly authorized attorn

October 13, 2021 EX-10.14

Form of Option Agreement under 2021 Science 37 Holdings, Inc. Incentive Award Plan.

Exhibit 10.14 SCIENCE 37 HOLDINGS, INC. 2021 INCENTIVE AWARD PLAN STOCK OPTION GRANT NOTICE Science 37 Holdings, Inc., a Delaware corporation (the ?Company?) has granted to the participant listed below (?Participant?) the stock option (the ?Option?) described in this Stock Option Grant Notice (this ?Grant Notice?), subject to the terms and conditions of the Science 37 Holdings, Inc. 2021 Incentive

October 13, 2021 EX-99.1

Science 37, the Operating System for Agile Clinical Trials, Closes Business Combination with LifeSci Acquisition II Corp. and Will Begin Trading on Nasdaq as SNCE

Exhibit 99.1 Science 37, the Operating System for Agile Clinical Trials, Closes Business Combination with LifeSci Acquisition II Corp. and Will Begin Trading on Nasdaq as SNCE ? Science 37 to debut on Nasdaq as a publicly traded company under ticker symbol ?SNCE? ? Business combination will provide Science 37 with approximately $235 million in cash proceeds to support continued growth ? Science 37

October 13, 2021 EX-10.15

Form of Restricted Stock Unit Agreement under 2021 Science 37 Holdings, Inc. Incentive Award Plan.

Exhibit 10.15 SCIENCE 37 HOLDINGS, INC. 2021 INCENTIVE AWARD PLAN RESTRICTED STOCK Unit Grant Notice Science 37 Holdings, Inc., a Delaware corporation (the ?Company?), has granted to the participant listed below (?Participant?) the Restricted Stock Units (the ?RSUs?) described in this Restricted Stock Unit Grant Notice (this ?Grant Notice?), subject to the terms and conditions of the Science 37 Ho

October 13, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant, Completion of Acquisition or Disposition of Assets, Material Modification to Rights of Security Holders, Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Change in Shell Company Status, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 6, 2021 Science 37 Holdings, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commissi

October 13, 2021 EX-99.2

UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

Exhibit 99.2 UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION Defined terms included below have the same meaning as terms defined and included elsewhere in Current Report on Form 8-K. The following unaudited pro forma condensed combined financial statements present the combination of the financial information of LSAQ and Science 37, adjusted to give effect to the Business Combination.

October 13, 2021 EX-21.1

Subsidiaries of the Company.

Exhibit 21.1 Subsidiaries of Science 37 Holdings, Inc. Jurisdiction of Name of Subsidiary Organization Science 37 s.r.o Slovak Republic Science 37 Switzerland GmbH Switzerland

October 13, 2021 EX-16.1

Letter from WithumSmith+Brown PC to the U.S. Securities and Exchange Commission dated October 13, 2021.

Exhibit 16.1 October 13, 2021 Office of the Chief Accountant Securities and Exchange Commission 100 F Street, NE Washington, DC 20549 United States of America Commissioners: We have read the statements of Science 37 Holdings, Inc. (formerly known as LifeSci Acquisition II Corp.) included under Item 4.01 of its Form 8-K dated October 13, 2021. We agree with the statements concerning our Firm under

October 13, 2021 EX-3.2

Amended and Restated By-Laws of LifeSci Acquisition II Corp.

Exhibit 3.2 Amended and Restated Bylaws of LIFESCI ACQUISITION II CORP. (a Delaware corporation) Table of Contents Page Article I - Corporate Offices 1 1.1 Registered Office 1 1.2 Other Offices 1 Article II - Meetings of Stockholders 1 2.1 Place of Meetings 1 2.2 Annual Meeting 1 2.3 Special Meeting 1 2.4 Notice of Business to be Brought before a Meeting. 2 2.5 Notice of Nominations for Election t

October 6, 2021 8-K

Regulation FD Disclosure, Submission of Matters to a Vote of Security Holders

United States SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 October 4, 2021 Date of Report (Date of earliest event reported) LifeSci Acquisition II Corp. (Exact Name of Registrant as Specified in its Charter) Delaware 001-39727 84-4278203 (State or other jurisdiction of incorporation) (Commis

September 24, 2021 424B3

PROPOSED MERGER YOUR VOTE IS VERY IMPORTANT

TABLE OF CONTENTS ? Filed Pursuant to Rule 424(b)(3)? ?Registration No. 333-258205? PROPOSED MERGER YOUR VOTE IS VERY IMPORTANT Dear Stockholders: You are cordially invited to attend the special meeting of the stockholders (the ?Meeting?) of LifeSci Acquisition II Corp. (?LSAQ?), which will be held at 10:00 a.m., Eastern Time, on October 4, 2021. The Meeting will be held via teleconference using t

September 21, 2021 CORRESP

LifeSci Acquisition II Corp. 250 W. 55th St., #3401 New York, New York 10019

LifeSci Acquisition II Corp. 250 W. 55th St., #3401 New York, New York 10019 September 21, 2021 VIA EDGAR & TELECOPY Scott Anderegg Jennifer L?pez-Molina Division of Corporation Finance Office of Trade & Services U.S. Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 RE: Lifesci Acquisition II Corp. (the ?Company?) Registration Statement on Form S-4 (File No. 333-258205)

September 16, 2021 SC 13G/A

LSAQ / Lifesci Acquisition II Corp / COWEN AND COMPANY, LLC - COWEN AND COMPANY, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* LifeSci Acquisition II Corp (Name of Issuer) Common Stock (Title of Class of Securities) 53229E103 (CUSIP Number) May 10, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

September 15, 2021 S-4/A

Amended and Restated Certificate of Incorporation.

TABLE OF CONTENTS As filed with the U.S. Securities and Exchange Commission on September 15, 2021. Registration No. 333-258205? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ? AMENDMENT NO. 2 to Form S-4 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ? LIFESCI ACQUISITION II CORP. (Exact name of registrant as specified in its charter) ? ? Delaware (State or o

August 31, 2021 EX-99.7

Consent of Emily Rollins to be named as a director.

Exhibit 99.7 Consent to be Named as a Director Nominee In connection with the filing by LifeSci Acquisition II Corp. of the Registration Statement on Form S-4 (the ?Registration Statement?) with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named as a nominee to the

August 31, 2021 EX-10.8

Form of Indemnification Agreement.

EXHIBIT 10.8 INDEMNIFICATION And Advancement AGREEMENT This Indemnification and Advancement Agreement (as amended or amended and restated, this ?Agreement?) is made as of [ l ], 2021 (the ?Effective Date?) by and between Science 37 Holdings, Inc., a Delaware corporation (the ?Company?), and , [ l ] of the Company (?Indemnitee?). RECITALS: WHEREAS, the Board of Directors of the Company (the ?Board?

August 31, 2021 EX-4.3

Form of Warrant Exchange Agreement between LSAQ and the Sponsor.

Exhibit 4.3 WARRANT EXCHANGE AGREEMENT This WARRANT EXCHANGE AGREEMENT dated as of , 2021, is by and between LifeSci Acquisition II Corp., a Delaware corporation (the “Company”) and LifeSci Holdings LLC, a Delaware limited liability company (“Holder”). WHEREAS, on November 24, 2020, the Company entered into a Private Warrant Agreement (the “Warrant Agreement”) by and between the Company and the Ho

August 31, 2021 S-4/A

As filed with the U.S. Securities and Exchange Commission on August 31, 2021.

TABLE OF CONTENTS As filed with the U.S. Securities and Exchange Commission on August 31, 2021. Registration No. 333-258205? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ? AMENDMENT NO. 1 to Form S-4 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ? LIFESCI ACQUISITION II CORP. (Exact name of registrant as specified in its charter) ? ? Delaware (State or othe

August 31, 2021 EX-99.8

Preliminary Proxy Card.

Exhibit 99.8 YOUR VOTE IS IMPORTANT. PLEASE VOTE TODAY. SPECIAL MEETING OF STOCKHOLDERS , 2021 This Proxy is Solicited On Behalf Of The Board Of Directors Vote Your Proxy by mail: Mark, sign and date your proxy card and return it in the postage-paid envelope provided. ?FOLD HERE ? DO NOT SEPARATE ? INSERT IN ENVELOPE PROVIDED ? THE BOARD OF DIRECTORS RECOMMENDS A VOTE ?FOR? PROPOSAL NOS. 1, 2, 3 (

August 31, 2021 EX-21.1

List of Subsidiaries.

Exhibit 21.1 List of Subsidiaries of LifeSci Acquisition II Corp. Name of Subsidiary Jurisdiction of Organization LifeSci Acquisition II Merger Sub, Inc. Delaware List of Subsidiaries of Science 37, Inc. Name of Subsidiary Jurisdiction of Organization Science 37 s.r.o Slovak Republic Science 37 Switzerland GmbH Switzerland

August 31, 2021 CORRESP

Via Edgar

Scott Anderegg Jennifer L?pez-Molina August 31, 2021 Page 1 Via Edgar August 31, 2021 Scott Anderegg Jennifer L?pez-Molina Division of Corporation Finance Office of Trade & Services U.

August 27, 2021 EX-21.1

List of Subsidiaries

Exhibit 21.1 List of Subsidiaries of LifeSci Acquisition II Corp. LifeSci Acquisition II Merger Sub, Inc., a Delaware corporation

August 27, 2021 EX-4.3

Description of Securities

Exhibit 4.3 DESCRIPTION OF REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of June 30, 2021, the end of the period covered by this Annual Report on Form 10-K, Lifesci Acquisition II Corp. (the ?Company,? ?we,? ?us,? or ?our?) had one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the ?Exchange

August 27, 2021 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30, 2021 or ? TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-39727 LIFESCI ACQUISITION II CORP. (Exact

July 28, 2021 S-4

Power of Attorney (included on the signature page hereto).

TABLE OF CONTENTS As filed with the U.S. Securities and Exchange Commission on July 27, 2021. Registration No. 333-???????? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ? Form S-4 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ? LIFESCI ACQUISITION II CORP. (Exact name of registrant as specified in its charter) ? ? Delaware (State or other jurisdiction of in

July 28, 2021 EX-99.2

Consent of John W. Hubbard to be named as a director.

EX-99.2 8 tm2118980d6ex99-2.htm EXHIBIT 99.2 Exhibit 99.2 Consent to be Named as a Director Nominee In connection with the filing by LifeSci Acquisition II Corp. of the Registration Statement on Form S-4 (the “Registration Statement”) with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the “Securities Act”), I hereby consent, pursuant to Rule 438 of the Securi

July 28, 2021 EX-99.6

Consent of Neil Tiwari to be named as a director.

Exhibit 99.6 Consent to be Named as a Director Nominee In connection with the filing by LifeSci Acquisition II Corp. of the Registration Statement on Form S-4 (the ?Registration Statement?) with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named as a nominee to the

July 28, 2021 EX-99.4

Consent of Adam Goulburn to be named as a director.

Exhibit 99.4 Consent to be Named as a Director Nominee In connection with the filing by LifeSci Acquisition II Corp. of the Registration Statement on Form S-4 (the ?Registration Statement?) with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named as a nominee to the

July 28, 2021 EX-10.16

Offer Letter by and between Science 37, Inc. and Stephen Geffon, dated November 13, 2019.

Exhibit 10.16 Steve Geffon November 13, 2019 12121 Bluff Creek Drive, Suite 100 Los Angeles, CA 90094 Phone: 984377.3737 Fax: 888.534.6531 November 13, 2019 Steve Geffon Re: Offer of Employment Dear Steve: On behalf of Science 37, Inc. ("Science 37"), I am pleased to offer you employment in the position of Chief Commercial Officer (CCO), reporting to Science 37's Chief Executive Officer. This lett

July 28, 2021 EX-99.3

Consent of Robert Faulkner to be named as a director.

Exhibit 99.3 Consent to be Named as a Director Nominee In connection with the filing by LifeSci Acquisition II Corp. of the Registration Statement on Form S-4 (the ?Registration Statement?) with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named as a nominee to the

July 28, 2021 EX-99.1

Consent of David Coman to be named as a director.

Exhibit 99.1 Consent to be Named as a Director Nominee In connection with the filing by LifeSci Acquisition II Corp. of the Registration Statement on Form S-4 (the ?Registration Statement?) with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named as a nominee to the

July 28, 2021 EX-10.17

Offer Letter by and between Science 37, Inc. and Jonathan Cotliar, dated October 20, 2016.

Exhibit 10.17 5875 Green Valley Circle, Suite 100 Culver City, CA 90230 Phone: 984.377.3737 Fax: 888.534.6531 October 20, 2016 Jonathan Cotliar, M.D. Re: Offer of Employment Dear Jonathan, On behalf of Science 37, Inc. (?Science 37?), I am pleased to offer you employment in the position of Vice President of Medical Affairs, reporting to Belinda Tan, M.D., Ph.D., Chief Medical Officer. Your respons

July 28, 2021 EX-99.5

Consent of Bhooshi DeSilva to be named as a director.

Exhibit 99.5 Consent to be Named as a Director Nominee In connection with the filing by LifeSci Acquisition II Corp. of the Registration Statement on Form S-4 (the ?Registration Statement?) with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the ?Securities Act?), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named as a nominee to the

July 28, 2021 EX-10.15

Offer Letter by and between Science 37, Inc. and David Coman, dated November 13, 2019.

Exhibit 10.15 David Coman November 13, 2019 12121 Bluff Creek Drive, Suite 100 Los Angeles, CA 90094 Phone: 984.377.3737 Fax: 888.534.6531 November 13, 2019 David Coman Re: Offer of Employment Dear David, On behalf of Science 37, Inc. ("Science 37"), I am pleased to offer you employment in the position of Chief Executive Officer, reporting to Science 37's Board of Directors (the "Board of Director

July 27, 2021 CORRESP

Via Edgar

Giovanni Caruso Partner 345 Park Avenue New York, NY 10154 Direct?????212.407.4866 Main???????212.407.4000 Fax??????????212.937.3943 [email protected] Via Edgar July 27, 2021 Scott Anderegg Jennifer L?pez-Molina Division of Corporation Finance Office of Trade & Services U.S. Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: Lifesci Acquisition II Corp. Draft Registrat

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